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Minimally invasive disc injection reduces pain and improves function in chronic back pain, feasibility study finds
Medical Xpress / Phys.org / BMC Musculoskeletal Disorders ^ | May 8, 2025 | Justin Jackson / Douglas P. Beall et al

Posted on 06/05/2025 8:30:48 PM PDT by ConservativeMind

VIVEX Biologics, Inc. sponsored research reports positive outcomes for patients with chronic lumbar discogenic pain treated using a single intradiscal injection of VIA Disc NP, an allogeneic nucleus pulposus product derived from cadaveric disc tissue.

Researchers conducted a prospective, single-arm clinical study at six U.S. sites to assess the impact of intradiscal injection of VIA Disc NP on back pain severity and functional impairment in patients with chronic lumbar discogenic pain unresponsive to conservative management.

A total of 28 adults were enrolled, with 22 participants completing the 12-month follow-up. Patients received a single injection of 100 mg of VIA Disc NP. Under fluoroscopic guidance, the product was delivered into targeted lumbar discs (L1-S1) through a spinal needle, with patients discharged the same day. Follow-up assessments occurred.

Study participants experienced a 43% reduction in back pain severity from baseline to 12 months.

Numeric Rating Scale (NRS) scores, a self-reported measure of pain intensity ranging from 0 (no pain) to 10 (worst possible pain), decreased from 7.1 at baseline to 3.8 at 12 months; 64% of participants achieved at least a 30% reduction in pain severity, and 55% reported a reduction of 50% or greater.

Nearly 60% of participants reported a pain severity score of 3 or less at 12 months, meeting the patient acceptable symptom state (PASS) threshold, which indicates a pain level perceived as manageable by the patient.

Oswestry Disability Index (ODI) scores, a standardized measure of disability related to low back pain that assesses functional impairment across daily activities, decreased by 50% from baseline to 12 months. Some 59% of participants achieved a clinically significant improvement in functional impairment, defined as a reduction of at least 30% from baseline. Severe or crippled impairment decreased from 82% of participants at baseline to 18% at 12 months.

(Excerpt) Read more at medicalxpress.com ...


TOPICS: Health/Medicine
KEYWORDS: back; disc; spine
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This is available today, and it appeared to provide a decent amount of benefit for the 12 month windows the study lasted.

A single injection was all that was done.

1 posted on 06/05/2025 8:30:48 PM PDT by ConservativeMind
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To: Mazey; ckilmer; goodnesswins; Jane Long; jy8z; ProtectOurFreedom; matthew fuller; telescope115; ...

The “Take Charge Of Your Health” Ping List

This high volume ping list is for health articles and studies which describe something you or your doctor, when informed, may be able to immediately implement for your benefit.

Email me to get on either the “Common/Top Issues” (20 - 25% fewer pings) or “Everything” list.

2 posted on 06/05/2025 8:31:38 PM PDT by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
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To: ConservativeMind

I have ongoing back pain from an old back injury and all they will do is “pain management”

“Take two aspirin and call in the morning”

Doing any sort of back surgery is apparently verboten to the health care bean counters.

Better to try and dull the pain than the expense of fixing the freaking problem.

Yes, I am pissed.


3 posted on 06/05/2025 9:23:11 PM PDT by doorgunner69 (Your oath of enlistment has no expiration date)
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To: All
intradiscal injection of VIA Disc NP, an allogeneic nucleus pulposus product derived from cadaveric disc tissue.

This sounds suspiciously like I'd be injecting a dead mans/womans disc tissue (from unknown blood type and/or unknown chronic diseases. But I could be wrong.


4 posted on 06/05/2025 9:24:04 PM PDT by BipolarBob (I worked at the circus as The Human Cannonball, until they fired me.)
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To: BipolarBob

“What, me worry”?


5 posted on 06/05/2025 9:25:04 PM PDT by BipolarBob (I worked at the circus as The Human Cannonball, until they fired me.)
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To: doorgunner69

This may help you, then.


6 posted on 06/05/2025 10:10:16 PM PDT by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
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To: BipolarBob

You would be correct.


7 posted on 06/05/2025 10:11:08 PM PDT by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
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To: ConservativeMind

Check out NEVRO COMPANY (California)
Spinal Cord Stimulator (SCS)
Model HFX
Works well at controlling pain. I have had one implanted (only goes under skin) for 10 years.


8 posted on 06/05/2025 10:39:43 PM PDT by carikadon (Don't mess with Texas)
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To: doorgunner69

Back surgery is extremely risky. I spent 8 weeks in a spinal rehab clinic with people who had very bad outcomes from their surgery.


9 posted on 06/05/2025 10:50:46 PM PDT by Nachoman (Proudly oppressing people of color since 1957.)
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To: ConservativeMind

What happened to the 6 people that didn’t complete the study? Drug studies tend to not mention WHY they didn’t complete the study. Are they still alive? Did they die the day after the injections? Those details matter.


10 posted on 06/05/2025 11:07:05 PM PDT by CFW
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To: CFW

Discogenic? No, thank you - I hated it the first time around.


11 posted on 06/05/2025 11:31:05 PM PDT by Wally_Kalbacken
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To: doorgunner69

If you have herniated discs try decompression. It elevated mt pain in 3 weeks. I still have to be careful lifting things but i went from not being able to stand up out oa chair to jumping right up.


12 posted on 06/06/2025 1:02:35 AM PDT by DainBramage
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To: ConservativeMind

Bkmk


13 posted on 06/06/2025 2:30:56 AM PDT by sauropod (Make sure Satan has to climb over a lot of Scripture to get to you. John MacArthur Ne supra crepidam)
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To: Nachoman; doorgunner69

Exactly my reaction on reading doorgunner69’s comment. Avoid surgery if at all possible! Which this injection may help people do.


14 posted on 06/06/2025 3:19:11 AM PDT by FreedomPoster (Islam delenda est)
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To: Nachoman
I don't regret my surgery one bit.

I had a herniated/ruptured L4/L5. Spent months on the couch or in bed, popping ibuprofen like candy, because I couldn't be on my feet for more than a few minutes without excrutiating pain.

The day after my microdiscectomy I got up and walked a mile and a half around my neighborhood. I didn't even bother taking the Norco the prescribed after the surgery. Still haven't had a hint of a problem going on 7 years now. I play hockey 3 times a week, and cummute daily on a sportbike, so it's not like I'm taking it easy or leading a sedentary lifestyle.

As to the article, when I had the consultation for my surgery, they offered (for a not unsubstantial cost) to inject stem cells into the disc. Apparently there is a chance they can "become" some of the disc material that was removed during the procedure.

15 posted on 06/06/2025 3:40:58 AM PDT by Christopher
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To: doorgunner69

My husband has been getting steroid injections to his back for years. He’s also on pain meds. The injections really help. They sedate him before the injections. They’re virtually painless.


16 posted on 06/06/2025 4:26:49 AM PDT by Flaming Conservative ((Pray without ceasing)
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To: ConservativeMind

My mother-in-law had this done, maybe with a different material. I worked well.


17 posted on 06/06/2025 5:56:17 AM PDT by Socon-Econ (adi)
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To: DainBramage

Aftermath of compression fractured lumbar vertebrae.

Spinal fusion and stainless rods to stabilize the mess still there after 40 years. Actually did well until a couple years ago and started getting severe brief pain episodes.

After waking up from the original surgery, believe me, have no desire to experience that again.

The are setting up to do an RF ablation on the nerves down there to control the pain.


18 posted on 06/06/2025 7:36:33 AM PDT by doorgunner69 (Your oath of enlistment has no expiration date)
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To: Flaming Conservative

They started doing the caudal steroid injections over a year ago. They have had varied effect and duration of relief.

As posted, the pain management guy wants to do an RF ablation on the nerves down there to diminish the pain.

My pain is usually tolerable and moderately debilitating. It is the sudden stabs that happen unexpectedly that are the killer.


19 posted on 06/06/2025 7:40:34 AM PDT by doorgunner69 (Your oath of enlistment has no expiration date)
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To: doorgunner69

My husband has also had RF abortions several times. They are more effective than the steroid injections.


20 posted on 06/06/2025 8:14:04 AM PDT by Flaming Conservative ((Pray without ceasing)
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