Posted on 05/22/2025 11:13:53 PM PDT by ransomnote
[H/T ExTexasRedhead]
SNIP
Comparing Drug Side Effect Information for 2 Identical Drugs (Ozempic and Wegovy):
You have, no doubt, heard about the GLP-1 agonist drugs Ozempic and Wegovy. They are both semaglutide. Ozempic was approved for diabetes and Wegovy was approved for weight loss. From our perspective, the clinical trials should have produced somewhat similar side effect profiles.
The official prescribing information reports that 20.3% of the patients on Ozempic complained of nausea while only 6.1% of those on placebo reported nausea. Contrast that with the identical medicine Wegovy: 42% to 44% of subjects on Wegovy reported nausea. Those getting placebo shots of Wegovy reported nausea 16-18% of the time.
Stop. Reflect! We are comparing nausea from placebo to nausea from placebo. Those getting placebo injections in the Wegovy trial had about 3 times the incidence of nausea than those getting placebo injections in the Ozempic trials. Smells kind of fishy, don’t you think?
Diarrhea was even more bizarre. Those getting placebo shots in the Ozempic clinical trials reported diarrhea 1.9% of the time. The subjects getting placebo shots in the Wegovy clinical trial reported diarrhea 16-19% of the time. That’s about a 10 fold difference. We’re talking placebo compared to placebo. It should not be different! Or, if there were a psychological factor at work, it should not have been that different! We think there is a BIG problem with how such side effect information is collected.
Overlooking Adverse Drug Reactions!
There is another very serious flaw in the way pharmaceutical companies collect drug side effect information. If they do not “catch” an adverse reaction during the smallish preliminary phase 2 safety studies, they are not likely to look for an adverse reaction during the major clinical trials.
Unfortunately, prescribers don’t always recognize this shortcoming. We can’t tell you how often a reader has written to say that their physician dismissed a problem with the drug because he or she couldn’t find the side effect listed in the prescribing information. Yet adverse effects often crop up long after drug approval.
MORE AT THE LINK:
https://www.peoplespharmacy.com/articles/why-you-cant-trust-drug-side-effect-information
If there were a psychological factor at work, it should not have been that different!
Why not? Ozempic is prescribed for people with DM2 who are most likely obese. Wegovy is for people who are obese without DM2. Two different populations and motivations.
A pharmacist recently told me the most frequent complaint he hears about the semaglutide drug class: "It makes me feel full, not hungry." Doh!
“If you have seasonal allergies, Mxyzptlkacine may be right for you. Side effects of Mxyzptlkacine are uncommon, and include headache, nausea, vomiting, death, dizziness, vaginal ejaculations, dysentery, cardiac arrhythmia, mild heart explosions, varicose veins, darkened stool, darkened soul, lycanthropy, trucanthropy, more vomiting, arteriosclerosis, hemorrhoids, diabeetus, virginity, mild discomfort, vampirism, gender impermanence, spontaneous dental hydroplosion, sugar high, even more vomiting, total scrotal implosion, brown, your mom, and mild rash.”
“If you have seasonal allergies, Mxyzptlkacine may be right for you. Side effects of Mxyzptlkacine are uncommon, and include headache, nausea, vomiting, death, dizziness, vaginal ejaculations, dysentery, cardiac arrhythmia, mild heart explosions, varicose veins, darkened stool, darkened soul, lycanthropy, trucanthropy, more vomiting, arteriosclerosis, hemorrhoids, diabeetus, virginity, mild discomfort, vampirism, gender impermanence, spontaneous dental hydroplosion, sugar high, even more vomiting, total scrotal implosion, brown, your mom, and mild rash.”
Statistics are based on 1 in a hundred, you are 1 in a million.
Double-edged sword - they send out questionnaires asking if a person on the drug experienced ...... if a person had an ear infection and had vertigo from it while on the drug - the questionnaire puts “vertigo” as a potential side effect.
You can’t pick out the actual from the far-fetched - but it’s obvious that a lot of the drugs do increase some serious risks - I hate it when they say the drug, “may help....” or “It is not known how it works....”
LOL!!
Anyone who actually reads the side effects of big pharma drugs would never take the drugs to begin with.
All drug ads should be removed for all media and left choice should be between the Dr and the patient. Big pharma should only be allowed to put out a list of what drugs are available and for what and a felony crime for any interactions between them and any doctor and/or medical facility with full liability for their products on the line when used.
Right...you should stop and reflect. You should also understand how this data is collected and reported.
You are using adverse events and percentages of incidence from two different populations: obese and those with diabetes. They are not the same. Full stop. End of story.
You're also dealing with much smaller numbers. Clinical trials try to obtain a diverse representation of the targeted population, but people are different. Some are more sensitive to feeling nausea than others. Statistics are extrapolated, but the potential adverse effects listed in the patient insert may not be what you experience. Even trial to trial, among patients with the same disease state the percentages of reported adverse events won't likely be the same.
There are people on FR that look for boogeymen behind every pharmacy bottle. In a few cases, it might be justified--I'm not excusing any of the C19 vaccines--but in a great majority of cases clinical trials follow the scientific method and are doing their best to offer life-saving or improving medicines.
These are the medical professionals who are constantly telling us not to trust what we read on the internet. They are whipping that phone out and researching right in front of me!
LOL, oh no, a rash!!!
Nausea. Yeh, because if you’re nauseous you dont eat. 😆
In the General/Chat forum, on a thread titled Why You Can’t Trust Drug Side Effect Information! | Doctors and patients rely on drug side effect information found in online databases. What if that evidence is flawed?, Lou L wrote: Lou L wrote: Right...you should stop and reflect. You should also understand how this data is collected and reported.
You are using adverse events and percentages of incidence from two different populations: obese and those with diabetes. They are not the same. Full stop. End of story.
ransomnote: No, not full stop and end of story. We can't rule out the possibility that the data is misreported. Both groups could have been higher, both groups could have been lower. One might have been higher. Just saying 'they are different' is an observation, not an explanation.
Covid Vax example: Peter Doshi (British Medical Journal) looked at Pfizer trial data. Pfizer used the PCR and separated trial participants (post exposure) into Covid Positive with symptoms, Covid Positive without symptoms, and Covid Negative with symptoms. Pfizer then ignored 'Covid Negative with symptoms' from that point forward. Doshi correctly wanted to know why they didn't investigate what sort of illness that last group had.
The answer could profoundly impact the 'efficacy' rating of the 'vaccine', and we now know that the vax was never tested for transmission, according to Pfizer (pg 46) and Moderna (page 48) FDA filing.
'Data Gaps'
Anyone younger than age 18 or older than age 55
Pregnant or lactating mothers
Auto-immune conditions
Immunocompromised individuals
No data on transmission of covid
No data on preventing mortality from covid
No data on duration of protection from covid
We also know that the PCR used during Covid, and for vaccine trials, tested for a 'related coronavirus' instead of testing for the presence of the actual Covid virus because the CDC said no isolated samples of Covid were available when it was developed.
Lou L wrote: You're also dealing with much smaller numbers. Clinical trials try to obtain a diverse representation of the targeted population, but people are different. Some are more sensitive to feeling nausea than others. Statistics are extrapolated, but the potential adverse effects listed in the patient insert may not be what you experience. Even trial to trial, among patients with the same disease state the percentages of reported adverse events won't likely be the same.
There are people on FR that look for boogeymen behind every pharmacy bottle. In a few cases, it might be justified--I'm not excusing any of the C19 vaccines--but in a great majority of cases clinical trials follow the scientific method and are doing their best to offer life-saving or improving medicines.
ransomnote:
When I looked for these side-effects of these weight loss drug profiles online, there was no mention of potential vision impairment. But if you search, you find data that should concern people.
We went blind after using weight-loss drugs like Ozempic and Mounjaro
EXCERPT:
A review conducted by physician-scientists from the University of Utah’s John A. Moran Eye Center published in JAMA Ophthalmology on January 30, 2025, looked at nine patients who reported vision loss after taking semaglutide or tirzepatide, the active ingredients in Ozempic, Wegovy, Mounjaro and Zepbound.They found the patients taking these drugs developed three potentially blinding conditions affecting the optic nerve — the part of the eye that sends visual signals to the brain.
Of the nine patients, seven reported NAION-like symptoms; one had papillitis, an inflammation of the optic nerve head; and one individual developed paracentral acute middle maculopathy, which can cause a blind spot in vision.
The January study came on the heels of July 2024 research from Mass Eye and Ear, a teaching hospital at Harvard Medical School. It found an association between semaglutides and an increased risk of NAION.
In the General/Chat forum, on a thread titled Why You Can’t Trust Drug Side Effect Information! | Doctors and patients rely on drug side effect information found in online databases. What if that evidence is flawed?, NautiNurse wrote: If there were a psychological factor at work, it should not have been that different!
Why not? Ozempic is prescribed for people with DM2 who are most likely obese. Wegovy is for people who are obese without DM2. Two different populations and motivations.
ransomnote: That's not an explanation - it's a detail which requires investigation. We don't know if the disparity is due to population, and/or other factors like incorrect reporting. For example, the drug cannot gain approval if the results are not better than placebo, so a drug company could elevate reporting for the placebo group to gain approval. Why assume the best outcome possible when pharma has shown its backside to the world and we're still dealing with the fallout?
Pfizer fought in court to refuse to release trial data for 75 years because what it reported to the public during vaccine rollout did not match what it found in it's trial data. Unfortunately, it looks like some are still willing to blindly trust pharma and make whatever necessary assumptions to excuse them.
NautiNurse wrote: A pharmacist recently told me the most frequent complaint he hears about the semaglutide drug class: "It makes me feel full, not hungry." Doh!
ransomnote: It's quite likely any experiencing gastric paralysis or blindness while taking these drugs would not go to a pharmacist for help.
I failed to get your name in the address field before replying:
https://freerepublic.com/focus/chat/4318643/posts?page=14#14
Diabetes is the single most common cause of gastric paralysis (aka gastroparesis). This occurs in diabetics who have never taken semaglutide or tirzepatide.
Diabetic retinopathy is another unfortunate condition which arises from uncontrolled blood sugar. Left unchecked, it causes a host of eye problems via damaged ocular blood vessels which lead to visual impairment and blindness. Again, this condition occurs in diabetics who have never taken semaglutide or tirzepatide.
Better luck next time, Grasshopper.
Again, my comments are not reflective of what happened during COVID, nor am I launching into a defense of them here. I commented on the Wegovy/Ozempic studies and the OP's post about side effects and their "analysis" of side effects.
In the General/Chat forum, on a thread titled Why You Can’t Trust Drug Side Effect Information! | Doctors and patients rely on drug side effect information found in online databases. What if that evidence is flawed?, Lou L wrote: I specifically mentioned C19 in my comment--that things happened during that time that from a clinical standpoint, I could not understand. I don't excuse the vaccine work that was done--it was all under the premise of an "emergency," and I did not see relevant data to support it. Again, my comments are not reflective of what happened during COVID, nor am I launching into a defense of them here. I commented on the Wegovy/Ozempic studies and the OP's post about side effects and their "analysis" of side effects.
(your prior post) Lou L wrote: Right...you should stop and reflect. You should also understand how this data is collected and reported.
(my prior post) "ransomnote: No, not full stop and end of story. We can't rule out the possibility that the data is misreported. Both groups could have been higher, both groups could have been lower. One might have been higher. Just saying 'they are different' is an observation, not an explanation.
I'm saying that Wegovy/Ozempic and other SG-1's were developed and authorized under the same FDA/CDC regime which presided over the Covid19 abuses including data collection and reporting and in many cases, withholding.
I also pointed to the disparity in the reporting of side-effects in my prior post. This was also a problem in C19 'shots'.
ransomnote:
When I looked for these side-effects of these weight loss drug profiles online, there was no mention of potential vision impairment. But if you search, you find data that should concern people.
We went blind after using weight-loss drugs like Ozempic and Mounjaro
Today I learned that these weight loss drugs are made from reptile venom. What could possibly go wrong?
https://freerepublic.com/focus/chat/4314335/posts?page=5070#5070
Disclaimer: Opinions posted on Free Republic are those of the individual posters and do not necessarily represent the opinion of Free Republic or its management. All materials posted herein are protected by copyright law and the exemption for fair use of copyrighted works.
