Posted on 04/20/2025 8:08:40 PM PDT by ConservativeMind
Major depressive disorder (MDD) affects approximately 280 million people globally and is one of the leading causes of disability. One in every three people suffering from MDD also has to deal with treatment-resistant depression (TRD), a condition where patients do not respond to at least two antidepressant trials.
Esketamine nasal spray, a rapid-acting anti-depressant, is known to be effective against TRD when administered alongside antidepressants like selective serotonin reuptake inhibitor (SSRI) or a serotonin-norepinephrine reuptake inhibitor (SNRI).
A study retrospectively compared the effectiveness of both the combinations in treating TRD and found that esketamine plus SNRI showed significantly better overall results than esketamine plus SSRI.
While the effectiveness of esketamine combined with either SSRI or SNRI in treating TRD has been widely explored, it has been unclear which pairing has the advantage in different clinical aspects.
To bridge this gap in understanding, this study analyzed a population-based sample of over 55,000 patients.
The patients were then split into two equal groups of those who received esketamine plus SSRI and esketamine plus SNRI.
SSRIs administered in the study comprised citalopram, escitalopram, fluoxetine, fluvoxamine, paroxetine, sertraline, and vilazodone. The SNRI group consisted of desvenlafaxine, duloxetine, levomilnacipran, milnacipran, and venlafaxine.
They observed an overall decline in primary outcomes; however, patients treated with esketamine and SNRI had significantly lower rates of all-cause mortality (5.3%), hospitalizations (0.1%), and depression relapses (14.8%) compared to those who received esketamine with an SSRI, where the risk rates were 9.1%, 0.2% and 21.2%, respectively.
Statistical analysis also revealed that over the five-year period, patients who got the SNRI combo showed a higher survival probability of 91.4% than those in the SSRI group with 86.9%.
Both the treatment plans reduced the number of suicide attempts, but the cases were lower in those who received an SSRI, 0.3% vs. 0.5%.
(Excerpt) Read more at medicalxpress.com ...
Just about every mass shooter has a history of being mentally unstable and most were being treated for symptoms at the time of the shootings.
Many had been treated for years and years. Not cases of take pill. Shoot.
A bad reaction (sleeplessness) to a common drug (for pain) had a doctor prescribe Elavil for me. It definitely helped jump that hurtle.
So so sorry. Heartbreaking.
“However did the human race survive the millions of years before Big Pharma rolled out its prescription pscychotropic brain poisons?”
They just laughed at the crybabies and told them to grow up... Bubble wrap wasn’t a thing yet.
They used homeopathic treatments...like Grandmoms saying “Get over it!”
“However did the human race survive the millions of years before Big Pharma rolled out its prescription pscychotropic brain poisons?”’
Mushrooms, peyote, Ayahuasca, etc...
It responds best to sunshine or Vitamin D supplements. I have watched it work multiple times now. Most, maybe all clinical or manic depression is a Vitamin D deficiency. Winter Blues is a real condition and responds immediately to Vitamin D supplementation. A chronically depressed recently ex heroin addict I am acquainted with started taking D supps at my suggestion and stopped her methadone after a month. She is fine now and makes a point of going to the beach or just walking on sunny days.
“However did the human race survive the millions of years before Big Pharma rolled out its prescription pscychotropic brain poisons?”
They SPANKED their kids for the first 4940 years of recorded civilization. Then Dr. Spock showed up...
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