Posted on 04/05/2025 2:10:05 PM PDT by ConservativeMind
The liver has a unique ability, regeneration. However, the liver stops regenerating in cases of diseases that involve chronic liver damage.
Research has discovered in animal models a previously unknown mechanism of liver regeneration. It is a process that is triggered very quickly, just a few minutes after acute liver damage occurs.
The authors write that nutritional glutamate supplementation can effectively promote liver regeneration and benefit patients with severe and chronic liver damage.
The results show that liver and bone marrow are interconnected by glutamate. After acute liver damage, liver cells, called hepatocytes, produce glutamate and send it into the bloodstream; through the blood, glutamate reaches the bone marrow, inside the bones, where it activates monocytes, a type of immune system cell.
Monocytes then travel to the liver and along the way become macrophages—also immune cells. The presence of glutamate reprograms the metabolism of macrophages, and these consequently begin to secrete a growth factor that leads to an increase in hepatocyte production.
In other words, a rapid chain of events allows glutamate to trigger liver regeneration in just minutes, through changes in the macrophage metabolism.
The study reveals that hepatocytes producing a protein known as glutamine synthetase, which regulates glutamate levels, play a key role in regeneration.
According to the group, when glutamine synthetase is inhibited, there is more glutamate in circulation, which accelerates liver regeneration. This is what happens when the liver suffers acute damage: glutamine synthase activity decreases, blood glutamate increases, and from there, the connection with the bone marrow is established.
The results have been tested with bioinformatics tools, using databases of mouse and human hepatocytes.
Djouder says, "dietary glutamate supplementation may simply be recommended in the future after liver extirpation, and also to reduce liver damage caused by cirrhosis, or other serious liver diseases."
(Excerpt) Read more at medicalxpress.com ...
It appears you can help your liver repair by nudging its available glutamate.
I wonder if monosodium glutamate is a helpful glutamate source.
I have a friend who lost his wife to cirrhosis. He had it as well. They were millionaires before they were 40. They partied hard.
Anyways, Scott reversed his by diet alone. He is now a sobriety coach. Does it for free. Scott Freda. You can find him on YouTube and x and other places. Good guy.
A normal supplement that supports the liver people can usually take safely is Milk Thistle.
The previous end-all, be-all for the liver was ‘silymarin’, a chemical in Milk Thistle. Several scientific studies suggest that substances in milk thistle (especially a flavonoid called silymarin) protect the liver from toxins.
Not only did it protect the liver from deadly toxins, such as that found in the death cap mushroom, but it slowed uptake of such toxins, giving more time for the protective effect, and it stimulated liver regeneration by as much as 1/3rd.
The toxin mentioned is so destructive that there have been cases where after it destroyed a liver, and the person got a liver transplant, there was enough toxin left in the blood to destroy the transplant liver.
He lives up by Lake Lewisville in TX. And he’s a really good cook and fun to be around. Really cool cat.
Talk about a great market nich. Hard Cider + Glutamate.
Choline is also said to be helpful.
Does MSG count? Mono sodium glutamate. I cook with it quite often.
Thanks for the article. I will follow up with some of the researchers as a ESLD Patient who has had bouts of hepatocellular cancer.
Interesting study. Hopefully a course of treatment will someday be developed from this.
Have you watched this or heard of the Doctor? He is trying to develop vaccines based on T-cells instead of the virus model.
I bring this up because you seem to have a handle on health issues.
Glutamine is an all around good supplement. It’s supposed to help with muscle regeneration and gut healing as well.
bump for later
Thanks
BKMK
I buy PPC PhosChol (PolyenylPhosphatidylcholine -900mg softgels - human form) for our rescue dog who has copper storage disease. Recommended by her liver specialist to help her liver heal.
“Does MSG count? Mono sodium glutamate. I cook with it quite often.”.
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One should check for self.
https://www.earthclinic.com/blog/msg-what-you-need-to-know.html
Oh yeah, I’d be choking people in the ER!
Very neat with the mushroom works except there are so many weird things about mushrooms. I consume a few but not very many.
My wife has been taking Milk Thistle and gets kind of upset when she runs out. Probly something to that one as well.
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