Free Republic
Browse · Search
General/Chat
Topics · Post Article

Skip to comments.

Fatty acids promote immune suppression and therapy resistance in triple negative breast cancer, study shows (Omega-6 fats)
Medical Xpress / Baylor College of Medicine / Immunity ^ | March 28, 2025 | Liqun Yu et al

Posted on 04/02/2025 3:28:00 PM PDT by ConservativeMind

A new study published in the journal Immunity reveals a mechanism that allows triple negative breast cancer (TNBC) to develop resistance to therapy.

Researchers showed that lipid accumulation in tumor cells and nearby immune cells promotes immune suppression, but disrupting lipid formulation reverses treatment resistance and the immunosuppressive microenvironment.

Standard-of-care treatment for TNBC includes chemotherapy and immunotherapy. However, some initially responsive tumors still develop recurrences. Researchers studied mouse models and found that TNBC cells that survived treatment accumulated lipid droplets containing Omega-6 fatty acids. Single-cell RNA sequencing revealed that neutrophils, a type of white blood cell, near the tumor cells also accumulated these lipids.

"We found the tumor cells give the lipid droplets to surrounding neutrophils. This shifted the function of the neutrophils from antitumor to tumor promotion," said Dr. Liqun Yu.

"The prevailing perspective in our field has focused on the role of fatty acid metabolism in regulating the immune response and therapeutic response. We found in this study that not only can fatty acids serve as an energy source, but they are also precursors of immunosuppressive signals the cancer cells can use to fight against our immune system," said Dr. Xiang H.-F. Zhang.

Researchers found they could reverse therapy resistance and the immunosuppressive microenvironment by disrupting lipid droplet formation. Blocking dietary intake of Omega-6 fatty acids also resensitized the tumors to chemotherapy and immunotherapy treatments.

"We can advise patients to consume a diet low in Omega-6 fatty acids, which is not significantly different from the general advice to lower red meat, fat and sodium intake. We also are exploring therapeutic options to block fatty acid accumulation and immunosuppressive signals between the cancer cells and the neutrophils," said Zhang, William T. Butler, M.D.,

(Excerpt) Read more at medicalxpress.com ...


TOPICS: Health/Medicine
KEYWORDS: breast; cancer; iwbg; omega6
Simply not eating Omega-6 fats resensitized the tumors to chemotherapy and immunotherapy.

For this cancer, that’s something that is truly needed. A coworker lived only a short time after finding out her triple-negative she thought was under control, had metastasized.

1 posted on 04/02/2025 3:28:00 PM PDT by ConservativeMind
[ Post Reply | Private Reply | View Replies]

To: Mazey; ckilmer; goodnesswins; Jane Long; jy8z; ProtectOurFreedom; matthew fuller; telescope115; ...

The “Take Charge Of Your Health” Ping List

This high volume ping list is for health articles and studies which describe something you or your doctor, when informed, may be able to immediately implement for your benefit.

Email me to get on either the “Common/Top Issues” (20 - 25% fewer pings) or “Everything” list.

2 posted on 04/02/2025 3:28:57 PM PDT by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
[ Post Reply | Private Reply | To 1 | View Replies]

To: ConservativeMind

Bkmk


3 posted on 04/02/2025 3:40:33 PM PDT by sauropod (Make sure Satan has to climb over a lot of Scripture to get to you. John MacArthur Ne supra crepidam)
[ Post Reply | Private Reply | To 1 | View Replies]

To: ConservativeMind

bookmark


4 posted on 04/02/2025 3:50:16 PM PDT by GOP Poet (Super cool you can change your tag line EVERYTIME you post!! :D. (Small things make me happy))
[ Post Reply | Private Reply | To 1 | View Replies]

To: ConservativeMind

"We can advise patients to consume a diet low in Omega-6 fatty acids, which is not significantly different from the general advice to lower red meat, fat and sodium intake."

False. They are incorrectly pushing the anti red meat/fat/sodium agenda. When I was having debilitating pain from an old childhood injury to my right hand, I stumbled across the role Omega-6 fatty acids play in promoting inflammation.

When I first studied this I read in sports medicine articles that we eat both Omega3 and Omega6, and that we need both, but balance is incredibly important.

I looked through my cupboards and went online to check to see if my nutritional intake included too much Omega 6s.

Every mayonaise, salad dressing and prepared food products throughout the store contain seed oils which typically had 10's of thousands of units of Omega 6's compared with a few hundred unites of Omega 3's.

Brian Cates wrote an article "What If Everything They've Been Telling Us About Food is... Wrong" in which he makes the case that Americans consuming butter and other animal fats were healthier before seed oils were promoted as 'healthy' replacements.

"By giving Americans the ‘expert’ advice that they needed to start chugging down ‘6-11 servings’ every day of ‘healthy whole grains’ and cook their food with seed oils while counseling them to also **reduce** the amount of meat and animal fats they were eating, Americans began ingesting way more carbohydrates and PUFA’s [that’s ‘polyunsaturated fatty acids, for those of you in Rio Linda…] every day than they’d been eating before."

ransomnote: Further, Cates makes the point that the government knowingly pushed Americans to change to seed oil consumption which would harm health.

There was no mystery here. The results were established and easily observable.

And yet…what ended up happening over the next 100 years?

Government ‘health’ experts working hand-in-glove with Big Food corporations convinced most Americans to stop cooking their food with butter, lard, and tallow, and instead use the new ‘Crisco’ and other highly processed seed oils and margarine. Because they claimed these new processed products were ‘healthier’.

ransomnote: When I eliminated most of the vegetable oils from my diet, the pain in my hand went away. That means I stopped buying oils and products containing soybean oil, canola oil, safflower oil, grapeseed oil,sunflower oil etc. etc. etc.

How many Americans with chronic inflammation and pain realize that 'vegetable oils' can boost inflammation like that? (olive oil, coconut oil, avocado oil and palm FRUIT oil have far less Omega 6's, but palm KERNAL oil is high in them). When trying to find the useful tables showing the Omega 6's for seed oils, I kept running into frantic articles in the MSM insisting that we must embrace seed oils and avoid animal fats.

Reducing Omega 6's was hard at first, when purchasing food. I've read that 30% of the calories in the average American diet comes from seed oils. Don't get me started on fast food! It's loaded with seed oils.

Researchers and their findings are typically ignored when they publish about the problem with Omega 6's, but MAHA is just a few months old. :D

Omega-6 vegetable oils as a driver of coronary heart disease: the oxidized linoleic acid hypothesis
James J DiNicolantonio 1,, James H O’Keefe 1

SNIP

"The Anti-Coronary Club trial found that more people died overall and due to heart disease when saturated fat was replaced with polyunsaturated fat.40 Recovered data from the Sydney Diet Heart Study also found that replacement of dietary saturated fats with omega-6 linoleic acid (from safflower oil and margarine) increased all-cause mortality, cardiovascular mortality and CHD mortality.41 Finally, recovered data from the Minnesota Coronary Experiment indicated that replacing saturated fat with omega-6 linoleic acid (from corn oil and margarine) significantly lowered serum cholesterol but did not reduce mortality and may have increased the risk of death in older adults.42 In fact, for each 30 mg/dL reduction in serum cholesterol, there was a 22% higher risk of death. More troubling was a significantly greater incidence of at least one MI confirmed by autopsy in the omega-6 intervention. The overall clinical trial evidence suggests no benefit of replacing saturated fat with omega-6 polyunsaturated fat and even possible harm."

SNIP

"In summary, numerous lines of evidence show that the omega-6 polyunsaturated fat linoleic acid promotes oxidative stress, oxidised LDL, chronic low-grade inflammation and atherosclerosis, and is likely a major dietary culprit for causing CHD, especially when consumed in the form of industrial seed oils commonly referred to as ‘vegetable oils’."


5 posted on 04/02/2025 4:30:34 PM PDT by ransomnote (IN GOD WE TRUST)
[ Post Reply | Private Reply | To 1 | View Replies]

To: ConservativeMind

Good insight on this Omega-6 issue:

https://medicalxpress.com/news/2025-04-uncovers-dietary-fat-fuel-cancer.html


6 posted on 04/09/2025 7:25:36 PM PDT by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
[ Post Reply | Private Reply | To 1 | View Replies]

Disclaimer: Opinions posted on Free Republic are those of the individual posters and do not necessarily represent the opinion of Free Republic or its management. All materials posted herein are protected by copyright law and the exemption for fair use of copyrighted works.

Free Republic
Browse · Search
General/Chat
Topics · Post Article

FreeRepublic, LLC, PO BOX 9771, FRESNO, CA 93794
FreeRepublic.com is powered by software copyright 2000-2008 John Robinson