Posted on 02/11/2025 8:40:24 PM PST by ConservativeMind
An antibiotic used to treat infective diarrhea could be an effective drug for a type of inflammatory bowel disease, a new study has found.
Results revealed that an antibiotic called vancomycin may also be effective in treating people who have a specific type of inflammatory bowel disease (IBD), which develops in the context of an incurable autoimmune liver disease called primary sclerosing cholangitis (PSC). Notably, four in five patients who participated in the study achieved remission after taking the drug as part of a clinical trial.
This study is significant, as several participants with this disease had not responded to other IBD treatments. Moreover, IBD and PSC are closely correlated, with most individuals who have PSC developing IBD, and up to 14% of patients with IBD also developing PSC. This increases the chances of needing colon surgery and getting colon or liver cancer, needing a liver transplant, and the overall risks of death.
Dr. Mohammed Nabil Quraishi said, "Our findings suggest that vancomycin could offer a new therapeutic option for patients with this challenging combination of IBD and autoimmune liver disease. While these results are preliminary, they provide a strong foundation for further research."
80% achieved clinical remission
As part of the trial, participants were treated with the oral antibiotic for four weeks and followed up for a further four weeks during which the medication was discontinued. After four weeks of treatment, 80% of patients achieved clinical remission with a significant decrease in inflammatory markers, and 100% showed mucosal healing. When treatment was stopped, symptoms returned. Vancomycin was also shown to induce changes in certain bile acids, which are now being further investigated to develop and refine treatments for IBD-associated PSC.
(Excerpt) Read more at medicalxpress.com ...
‘Notably, four in five patients who participated in the study achieved remission after taking the drug as part of a clinical trial’
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Results on FIVE patients are .not. ‘notable’, they are anecdotal like they say it all the time with thousands of testimonies of complete remission using the carnivore diet.
And of course, side effects of antibiotics on the gut biomes are devastating and are not addressed.
Yet another stupid research dressed up as ‘science’.
It works on C-diff also.
And C Difficle may be a contributor to IBD and other colon issues. It’s more common than doctors realize.
One of my doctors said that my C-diff was probably encouraged or caused by the Amoxicillin I had been taking. I was originally diagnosed with Listeria. That was based on my having eaten some frozen waffles that had tested positive for Listeria.
Bkmk
The medicine I take for my colitis lowers my immune system. I now have permanent eye damage in one eye. Pretty much all drugs have a side effect.
Too bad this study didn’t come out years earlier. I hope other will benefit from it. It’s great to see they’re making some progress with IBD research. I was diagnosed with UC in ‘94.
CM, thanks for posting this. You are one of FreeRepublic’s treasures.
Can I ask what medicine you’re taking? I’m on Entyvio infusions, one every 8 weeks. So many drugs and different reactions in different people. Also I’m on Tacrolimus for my transplant. I’m doing ok so far (knock on wood).
When I had malaria, I felt like I would have to get better to die.
C-diff was the same. I’m not sure I’m completely over it.
Hang in there 👍🙂
I hate to hear that. I’ve had ulcerative colitis for years, at least that’s what they say. I’ve been taking mesalamine for the last year or so. I don’t really think it helps much. May I ask what you take that lowers your immune system?
I’m beginning to think that CDiff plays a much bigger role in these diseases, even colon cancer but doctors seem to think it’s rather rare and don’t test for it even though we take antibiotics a lot. I think the medical community needs some schooling from patients. Pretty easy equation and the cant figure it out
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