Posted on 02/07/2025 8:10:13 PM PST by ConservativeMind
A team of scientists has designed a strategy for preventing the cardiotoxic effects of anthracyclines, a widely used class of anticancer drugs.
Cardiotoxicity is a frequent adverse secondary effect of cancer therapy with these drugs. The study demonstrates that treatment with the SGLT2 inhibitor empagliflozin can mitigate the cardiac injury associated with anthracycline therapy.
Anthracyclines are first-line medications in the treatment of cancer, but in 5% of patients their use is associated with severe cardiotoxicity, leading to chronic heart failure.
"Although anthracycline cardiotoxicity has been known about for decades, effective preventive therapies have been lacking due to limited knowledge of the mechanisms involved," explained Dr. Borja Ibáñez.
Using an advanced experimental model, the CNIC team showed that administration of a 20 mg daily dose of empagliflozin preserved the contractile function of the hearts of pigs treated with anthracyclines and protected the metabolism of the heart muscle. A key feature of the study was the use of advanced diagnostic techniques, including magnetic resonance imaging and spectroscopy, to monitor heart function.
"The use of cutting-edge technologies with clinical applications lends significant translational value to this study. At the CNIC we are committed to using advanced technologies to generate findings that can be rapidly transferred to patients," commented Dr. Valentín Fuster.
The protective effect of empagliflozin identified in the study involves an increase in the myocardial consumption of ketone bodies. This preserves the production of ATP (adenosine triphosphate, the main source of transferable energy in living cells) and mitochondrial function.
"Treatment with empagliflozin protects the heart by directly addressing the metabolic processes affected by the cancer therapy," said Dr. Ibáñez.
(Excerpt) Read more at medicalxpress.com ...
Ivermectin has been classified as Anti Cancer since 2019.
Don’t know if you posted on the following or not? Saw on news tongiht that there is a blood test for colon cancer (not sure if the whole digestive tract is involved or not) that is about 80% accurate, which would practically eliminate need for frequent colonoscopy tests. Would be nice if it were a bit more accuratE, but 80% is pretty good- but of course with cancer, there is no “do over” meaning that if a person is one of the 20%, and they didn’t get colonoscopy and relied solely on the blood tests, they might not find out about the cancer until too late. But still, the blood test can be of help as it can be done cheaper, and more frequently to alert if there is a problem, then a colonoscopy can be ordered
I was on one of them - I refused the 3rd dose because the second one almost killed me - my new cardiologist said that the one I was on was brutal for relatively healthy 3=-40 year olds and should not have been given to a 70+ person - fortunately, my heart seems to have recovered.
Whew, looks like you got lucky. Just don’t understand why they keep pushing crap that makes things worse.
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