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Aerobic exercise: A powerful ally in the fight against Alzheimer's (Up to 76% improvement)
Medical Xpress / University of Bristol / Brain Research ^ | Jan. 16, 2025 | R.C. Gutierre et al

Posted on 01/21/2025 6:31:13 PM PST by ConservativeMind

Regular aerobic exercise could significantly reduce disease markers associated with Alzheimer's, research has found. The findings provide new hope in the battle against this devastating disorder.

The study highlights how physical activity not only protects healthy brain cells but also restores balance in the aging brain.

The research focused on the hippocampus, the brain region responsible for memory and learning, and measured the impact of aerobic exercise on key Alzheimer's markers: amyloid plaques, tau tangles, and iron accumulation in myelin-producing cells known as oligodendrocytes. These markers are central to Alzheimer's pathology.

Findings revealed that rodents who completed a structured aerobic exercise program experienced:

—Significant reductions in tau tangles (around 63% with exercise), amyloid plaques (about 76% in the exercise group), and iron accumulation (reduced by about 58% in the brains of exercising rodents).

—Enhanced brain cell health, including increased numbers of protective oligodendrocytes.

—Reduced brain inflammation in the exercise group (between 55% and 68% depending on the inflammatory biomarker considered), and cell death. Improved communication between brain cells, restoring critical balance in the brain's function as it ages.

Dr. Augusto Coppi explained, "Alzheimer's is a progressive neurodegenerative disorder with no known cure, impacting millions worldwide. While physical exercise is known to reduce cognitive decline, the cellular mechanisms behind its neuroprotective effects have remained elusive—until now.

"This research highlights the potential for aerobic exercise to serve as a cornerstone in preventive strategies for Alzheimer's."

(Excerpt) Read more at medicalxpress.com ...


TOPICS: Health/Medicine
KEYWORDS: aerobicexercise; alzheimers; dementia; inflammation; mentalhealth
Big improvements from exercise:

“—Significant reductions in tau tangles (around 63% with exercise), amyloid plaques (about 76% in the exercise group), and iron accumulation (reduced by about 58% in the brains of exercising rodents).

—Enhanced brain cell health, including increased numbers of protective oligodendrocytes.

—Reduced brain inflammation in the exercise group (between 55% and 68% depending on the inflammatory biomarker considered), and cell death. Improved communication between brain cells, restoring critical balance in the brain's function as it ages.”

1 posted on 01/21/2025 6:31:13 PM PST by ConservativeMind
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To: Mazey; ckilmer; goodnesswins; Jane Long; jy8z; ProtectOurFreedom; matthew fuller; telescope115; ...

The “Take Charge Of Your Health” Ping List

This high volume ping list is for health articles and studies which describe something you or your doctor, when informed, may be able to immediately implement for your benefit.

Email me to get on either the “Common/Top Issues” (20 - 25% fewer pings) or “Everything” list.

2 posted on 01/21/2025 6:31:38 PM PST by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
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To: ConservativeMind

I was having chronic back issues when I would do yard work (62 years old) and I started walking a mile and a half everyday with my yellow lab and about 3-4 times a week, I add another 2.5 miles on my treadmill and my back issues ave gone away. Took the dog yesterday and today (around 10-15 degrees) for our walk but it was at a faster pace.


3 posted on 01/21/2025 6:39:54 PM PST by Mean Daddy (Every time Hillary lies, a demon gets its wings. - Windflier)
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To: ConservativeMind

What does it mean when I keep forgetting to exercise...


4 posted on 01/21/2025 6:40:21 PM PST by Organic Panic (Democrats. Memories as short as Joe Biden's eyes)
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To: ConservativeMind

Wasn’t this already well known?


5 posted on 01/21/2025 6:57:56 PM PST by Mariner (War Criminal #18)
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To: Mariner
"Wasn’t this already well known?"

That's what happens when you forget to read the entire excerpt:

Dr. Augusto Coppi explained, "Alzheimer's is a progressive neurodegenerative disorder with no known cure, impacting millions worldwide. While physical exercise is known to reduce cognitive decline, the cellular mechanisms behind its neuroprotective effects have remained elusive—until now.

6 posted on 01/21/2025 7:18:41 PM PST by ProtectOurFreedom (They were the FA-est of times, they were the FO-est of times.)
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To: ConservativeMind

But will the hour I spent spinning my indoor cycle-trainer successfully counteract the 2 pieces of bacon I had today? A different article I read on Fox today said I’m doomed!


7 posted on 01/21/2025 7:24:00 PM PST by oldplayer
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To: ConservativeMind

Wow! Tremendous improvement! I wonder though how much help it is if the person is already fairly g advanced alzheimer’s?


8 posted on 01/21/2025 8:08:37 PM PST by Bob434
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To: ConservativeMind

Most research these days is highly suspect because our trust gets constantly shaken, but this one seems obviously true. With AI and supercomputer smartphones, we are entering a golden age of health research. Soon, millions of people’s smart phones will double as bodycams, quietly recording every single action in detail, every sip of water, every bite of food, every step, and AI will study and document the activity, then upload it to the cloud. Researchers will have an abundance of quality double-blind data to study anything in retrospect.


9 posted on 01/21/2025 8:32:03 PM PST by Reeses
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To: Organic Panic

It could mean that you have contracted a rather serious condition that makes it much more likely you will have higher blood pressure, increased risk of heart conditions, poor bone strength and susceptibility to breaks, increased risk of falls, and higher rates of depression:

Noun: procrastination
1. The act of procrastinating; putting off or delaying or deferring an action to a later time
2. Slowness and forgetfulness as a consequence of not getting around to it.

https://www.cdc.gov/physical-activity-basics/health-benefits/older-adults.html

#wink#


10 posted on 01/24/2025 8:20:39 AM PST by mbj
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