Posted on 10/20/2024 11:00:21 AM PDT by ConservativeMind
Acute pancreatitis (AP), which affects people of all ages, is one of the leading causes of hospital admission due to gastrointestinal diseases.
To date, many questions regarding the optimal treatment of acute pancreatitis remain unanswered.
A team combined human genetic epidemiology and animal models to discover and confirm the role of vitamin B12 in the prevention and mitigation of acute pancreatitis.
Fan explained that the team first conducted meta-analyses of genome-wide association studies (GWAS). They then employed a Mendelian randomization approach to investigate the relationships between various one-carbon metabolism nutrients and the risk of pancreatitis. The analysis revealed that higher serum vitamin B12 levels were strongly associated with a reduced risk of developing different types of pancreatitis.
Next, the team determined whether vitamin B12 displayed protective and potential therapeutic effects using experimental models of pancreatitis in CD320 knockout mice, which lack a key gene responsible for vitamin B12 absorption.
The results revealed that VB12 directly protects acinar cells from necrosis during the early stages of acute pancreatitis and subsequently reduces T lymphocyte infiltration. Notably, artificially increasing serum B12 levels before and after the induction of pancreatitis not only reduced the severity of the condition but also promoted tissue repair after pancreatic injury.
Vitamin B12 was found to enhance ATP production in pancreatic tissue, thereby reducing acinar cell necrosis and preventing disease progression.
ATP supplementation in CD320-deficient mice also alleviated pancreatic damage, further supporting the hypothesis that vitamin B12's protective effects result from improved cellular energy supply rather than oxidative stress regulation.
"These findings add evidence that vitamin B12 can reduce the severity of acute pancreatitis by increasing ATP levels in pancreatic tissue, offering insights into potential therapeutic strategies for this disease. This study lays a robust foundation for clinical applications of vitamin B12 in managing acute pancreatitis," Prof. Mo concludes.
(Excerpt) Read more at medicalxpress.com ...
Vitamin B-12 is a very simple and cheap therapy to give anyone.
So basically we should be eating more meat. Less carbs and fruits.
When I had Covid, I took B12, C, D3 and Zinc. Also drank boost in my coffee. Still do it 3 years later and only had the first pfizer with its booster. Never had it again.
My wife’s family are fully vaxxed and they all have had Covid multiple times. They still tell me, “ being vaxxed means you won’t get it as bad.”
Definitely should be eating less carbs. All the grains pushed by the health establishment (plus the high fructose corn syrup dumped into everything) appear to be behind the epidemic of obesity in our country.
“So basically we should be eating more meat. Less carbs and fruits.”
Yep, my first thought too - no brainer on that!
Seems like B-12 is therapeutic for many physical ailments...
Bump for reference.
However, there is B-12 and then there is B-12. Methylcobalamin and Andenosylcobalamin are not derived by cyanide.
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