Doxorubicin + trabectedin tied to increased survival in metastatic leiomyosarcoma

Medical Xpress / HealthDay / New England Journal of Medicine ^ | Sept. 6, 2024 | Elana Gotkine / Patricia Pautier et al / Robert S. Benjamin et al

[ConservativeMind]

For patients with metastatic or surgically unresectable leiomyosarcoma, combination therapy with doxorubicin and trabectedin is associated with improved overall and progression-free survival compared with doxorubicin alone, according to a study.

Patricia Pautier, M.D. and colleagues conducted a Phase III trial involving 150 patients with metastatic or unresectable leiomyosarcoma who had not received chemotherapy.

Patients were randomly assigned to doxorubicin (six cycles) or doxorubicin plus trabectedin (six cycles), with continued trabectedin as maintenance therapy in patients in the doxorubicin-trabectedin group without disease progression. After six cycles of therapy, surgery was allowed to resect residual disease in each group.

The researchers found that at a median follow-up of 55 months, 47 and 60 patients in the doxorubicin-trabectedin and doxorubicin groups, respectively, had died. Median overall survival was longer in the doxorubicin-trabectedin group versus the doxorubicin group (33 versus 24 months; adjusted hazard ratio for death, 0.65).

Progression-free survival was longer in the doxorubicin-trabectedin group versus the doxorubicin group, in a finding consistent with earlier reports (12 versus six months; adjusted hazard ratio for progression or death, 0.37).

[ConservativeMind]

One extra added treatment, trabectedin, greatly benefited these cancer patients.

[ConservativeMind]

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[Mr. K]

I think those are made up words

[blueunicorn6]

I enjoy the varied content on Free Republic.

I am not a physician and this article is hard for me to understand.

It is apparently important to you as you posted it here.

Perhaps you could give an everymans abstract about this article.

[WASCWatch]

This new drug combination may or may not extend life by 9 months, but it isn’t even close to being a cure.

[irishjuggler]

I’m not a doctor either, but I have some familiarity with the disease as a family member was once (tentatively) misdiagnosed with having it. It’s a cancer of the smooth muscles that shows up in organs like the uterus, intestines, stomach etc. It’s a particularly nasty cancer that can quickly spread to the lungs, liver, etc. This article is saying that a combination of 2 chemo drugs improves survival compared to each of the drugs alone.

[Delta 21]

Probly best I dont even ask. I dont need to be catching anything that sounds as bad as this does.

[blueunicorn6]

Thank you.

[blueunicorn6]

Thank you.