Posted on 09/02/2024 10:07:24 PM PDT by ConservativeMind
The elimination of damaged cell components is essential for the maintenance of the body's tissues and organs. An international research team has made significant findings on mechanisms for the clearing of cellular wastes, showing that strength training activates such mechanisms. The findings could form the basis for therapies for heart failure and nerve diseases.
Muscles and nerves are long-lasting, high-performance organs whose cellular components are subject to constant wear and tear. The protein BAG3 plays a critical role in the elimination of damaged components, identifying these and ensuring that they are enclosed by cellular membranes to form an "autophagosome."
Autophagosomes are like a garbage bag in which cellular waste is collected for later shredding and recycling. The team has shown that strength training activates BAG3 in the muscles. This has important ramifications for cellular waste disposal because BAG3 has to be activated to efficiently bind damaged cell components and promote membrane envelopment.
An active elimination or clearing system is essential for long-term preservation of muscle tissues. "Impairment of the BAG3 system does indeed cause swiftly progressing muscle weakness in children as well as heart failure," Professor Höhfeld explains.
Professor Sebastian Gehlert emphasizes how important the findings are, saying, "We now know what intensity level of strength training it takes to activate the BAG3 system, so we can optimize training programs for top athletes and help physical therapy patients build muscle better." Professor Gehlert also makes use of these findings to support the German Olympic team.
The BAG3 system is not only active in the muscles. Mutations in BAG3 can lead to a nerve disease known as Charcot-Marie-Tooth syndrome (named after the discovering scientist). The disease causes nerve fibers in the arms and legs to die off.
"…BAG3 is phosphorylated in resting muscles, and the phosphate groups are removed during activation."
(Excerpt) Read more at medicalxpress.com ...
This could be a bigger health benefit than is being mentioned here, in my opinion.
From a quick skim of pthe paper, it seems “cyclic stretching” is key:
“Strikingly, cyclic stretch resulted in a strong dephosphorylation of BAG3 within the first hour of treatment, before phosphorylation returned to control level at 4 h (Figure 1E).”
I don’t think this means “stretching,” as we would think it, as the writeup speaks to “intensity level of strength training,” but you should hit it well with both stretching and multiple repetitions.
I did not skim the whole paper to get all the details.
In other words,
“MOVE”
Moving your body/muscles is how you move the lymph fluid around your body. The lymph system is the system that is the sewer drain that brings cellular waster to be recycled or eliminated, but theres no heart providing pressure to move the fluid, body movement is mainly what does it. So that means exercise, stretching, massage. Not sure why they think this is a new thing, its well-known already.
Make me think the authors may have an interest in a gym company, or were paid to write it this way.
.
There is much talk about rebounding to get the lymph system moving. Dr. Berg has a YT vid on the mechanics of the thing. Is low-impact for oldies like me!
I could not find any vid by him on lymph and strength training
Not move, but “pick up heavy things and put them down.”
Of all your posts this year, this one actually makes the grade.
No offense. I’m shocked that it even got published. Yes, color me jaded on nearly all medical research/reporting.
The question now is whether this will have any impact upon the greater populace and/or government policies and/or the IFC (industrial food complex).
I predict statistically zero on all counts (i.e., it will either be ignored or demonized/discredited).
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