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Duloxetine may help elderly with depression and cognitive impairment
Medical Xpress / Karolinska Institutet / ACS Omega ^ | Aug. 29, 2024 | Taher Darreh-Shori et al

Posted on 09/02/2024 10:09:28 AM PDT by ConservativeMind

An already registered antidepressant, duloxetine, may also have positive effects on memory and cognitive functions in the elderly.

A new study shows that duloxetine, in addition to treating depression, also inhibits an enzyme involved in the regulation of the nervous system that affects memory and cognition. This could potentially prevent the development of dementia diseases, especially Alzheimer's disease.

"Both depression and cognitive impairment often occur simultaneously in elderly individuals, particularly those in the early stages of a dementia disease," says Taher Darreh-Shori. "The discovery that duloxetine can have a dual effect is very promising."

"This has been an unexpected discovery alongside our main research," says Taher Darreh-Shori. "We hope to conduct a clinical study on patients in the early stages of Alzheimer's disease."

The results are important because there are currently no drugs that cure dementia diseases. The fact that an already registered drug can help both with depression and cognitive impairment can be appreciated by both the medical community and elderly associations.

(Excerpt) Read more at medicalxpress.com ...


TOPICS: Health/Medicine
KEYWORDS: cognitivedecline; cognitiveimpairment; depression; duloxetine; elderly; medicalxpress
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To: Does so

Doctor in America who did the EMG test said it was mild and idiopathic. But I’ll tell you what, if this is mild, I’d hate to feel what moderate to severe feels like!

I take the same thing 600mg 2x a day. I don’t seem to have any side-effects.

How severe is yours?


21 posted on 09/03/2024 8:24:27 AM PDT by StayoutdaBushesWay (Trust in the Lord with all your heart, and lean not on your own understanding...)
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To: ConservativeMind
This helps too:


22 posted on 09/03/2024 8:26:30 AM PDT by central_va (I won't be reconstructed and I do not give a damn...)
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To: StayoutdaBushesWay

Great that it’s so effective for you!


23 posted on 09/03/2024 11:21:18 AM PDT by steve86 (Numquam accusatus, numquam ad curiam ibit, numquam ad carcerem™)
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To: StayoutdaBushesWay

“...to have any side-effects.

How severe is yours?”

“Side-effects” are dizziness and sleepiness. (These, somewhat worse at 3x300mg).

When I asked my (now retired) doctor to increase my dose, he (or Walgreens) simply DOUBLED my dosage, which I totally couldn’t handle.

Two years later, my newest doctor has me, as above, at a REDUCED 2x300mg—which is nearly undetectable.

I don’t know why Walgreens couldn’t give me the 3x600mg previously prescribed, but glad they stopped short.

As for getting away from prescriptions over-time, my Cardiologist handed me a handwritten calendar to get off the prescription in about six weeks.
Metoprolol? Clopidogrel?

I need some Adderol.

:-/


24 posted on 09/03/2024 11:51:10 AM PDT by Does so (Our Zoo-Animals are Safe--For Now...! 🇺🇦.....)
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To: StayoutdaBushesWay

At my Neurologist’s, I recounted two problems in addition to my PN and RLS.

That was the morning “purring” in my torso and the “essential tremor” at my lower jaw.

The torso discomfort would wake me up in the wee hours, but the Neurologist said those were “idiopathic”, and don’t come back...!


25 posted on 09/04/2024 2:24:02 AM PDT by Does so (Why is our print-media being crafted by foreigners? 🇺🇦.....)
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