New discovery leads to novel probiotic for eczema

Medical Xpress / NIH/National Institute of Allergy and Infectious Diseases / ^ | June 26, 2024 | Ian Myles, M.D., M.P.H. et al

[ConservativeMind]

Research has led to the availability of a new over-the-counter topical eczema probiotic. The probiotic is based on the discovery by scientists that bacteria present on healthy skin called Roseomonas mucosa can safely relieve eczema symptoms in adults and children.

Eczema—also known as atopic dermatitis—is characterized by dry, itchy skin that can compromise the skin's barrier, which functions to retain moisture and keep out allergens. This can make people with eczema more vulnerable to bacterial, viral and fungal skin infections. R. mucosa is a commensal bacterium, meaning it occurs naturally as part of a typical skin microbiome. Individuals with eczema experience imbalances in the microbiome and are deficient in certain skin lipids (oils). Researchers demonstrated that R. mucosa can help restore those lipids.

Scientists found specific strains of R. mucosa reduced eczema-related skin inflammation and enhanced the skin's natural barrier function in both adults and children. They isolated and cultured R. mucosa in the laboratory, conducted preclinical (laboratory/animal) and clinical (human) studies, and made the bacteria available for commercial, non-therapeutic development. The R. mucosa-based probiotic released this week is formulated by Skinesa and called Defensin.

In Phase 1/2 open-label and Phase 2 blinded, placebo-controlled clinical studies, most people experienced greater than 75% improvement in eczema severity following application of R. mucosa. Improvement was seen on all treated skin sites, including the inner elbows, inner knees, hands, trunk and neck. The researchers also observed improvement in skin barrier function. Additionally, most participants needed fewer corticosteroids to manage their eczema, experienced less itching, and reported a better quality of life following R. mucosa therapy. These benefits persisted after treatment ended: therapeutic R. mucosa strains remained on the skin for up to eight months in study participants who were observed for that duration.

[ConservativeMind]

The ointment is available without a prescription and a greater than 75% improvement was seen by patients. Even eight months after it was last applied, patients had the same benefit.

[ConservativeMind]

Defensin by Skinesa, available here:

https://www.skinesa.com/

[ConservativeMind]

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[Pete from Shawnee Mission]

CM. I do not see R. Mucosa in the ingredients. (This looks very similar to Stoneyfield Yoghurt!)

Not saying it does not work, but looks like a different product.

Skinesa® Ingredients

Bifidobacterium lactis BPL1 (CECT 8145)

Bifidobacterium longum ES1 (CECT 7347)

Lactobacillus casei (CECT 9104)

Lactobacillus rhamnosus (CECT 8361)

Lactobacillus rhamnosus (CNCM I-4036)

Here is another article about Defensin. (It may not be on the market yet?)

Skinesa formulates topical probiotic following NIAID discovery of eczema-fighting bacteria

snip...

03 Jul 2024 --- Scientists at the US National Institute of Allergy and Infectious Diseases (NIAID) say Roseomonas mucosa, a naturally occurring bacterium on healthy skin, can effectively treat eczema in adults and children. That has led to the development of Defensin by Skinesa, a new over-the-counter topical probiotic for eczema.

[ConservativeMind]

My guess, since it’s named the same, is that a change in the formulation is happening now.

[tinamina]

All the same probiotics are available at Costco sold by a company called true nature for $20 for 100 pills. I just happen to buy them last week and compare the Labels. Much better deal with Costco obviously