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Pilot study provides 'blueprint' for evaluating diet's effect on brain health
Medical Xpress / Johns Hopkins University / Cell Metabolism ^ | June 25, 2024 | Dimitrios Kapogiannis et al

Posted on 07/07/2024 6:59:57 PM PDT by ConservativeMind

Researchers say their study of 40 older adults with obesity and insulin resistance offers important clues about the potential benefits of both eating plans on brain health.

The new study tested the effects of intermittent fasting on women and men at risk for cognitive impairment.

The results revealed that both types of diet plans had benefits regarding decreasing insulin resistance and improving cognition, with improvements in memory and executive function with both diets, but more strongly with the intermittent fasting diet, according to Mark Mattson, Ph.D.

To test the effects of the two diets on brain function biomarkers, participants in the new study were recruited from June 2015 and December 2022, and four in-person assessments were completed at facilities.

Among the participants, 40 completed their eight-week study. Also, 20 were assigned to an intermittent fasting diet that restricted calories to one-quarter of the recommended daily intake for two consecutive days per week, and they followed the USDA's healthy living diet—which consists of fruits, vegetables, whole grains, lean proteins, low-fat dairy products and limited added sugars, saturated fats and sodium—for the remaining five days. The USDA's healthy living diet was assigned to 20 other study participants each day of the week.

The average age of participants in both groups was 63. All were obese and had insulin resistance.

The researchers found that both diets had equally positive effects on reducing insulin resistance markers in extracellular vesicles, improving BrainAGE (a measurement of the brain's biological age using structural MRI data) and lowering glucose concentration in the brain. Reduced glucose concentration is a corollary of higher glucose use.

Both diets also improved customary measurements of metabolic health.

Executive function and memory improved approximately 20% more in the intermittent fasting group than in the healthy living diet group.

(Excerpt) Read more at medicalxpress.com ...


TOPICS: Health/Medicine
KEYWORDS: diet; fasting
Both diets helped, but intermittent fasting gave a 20% edge in memory and executive memory (planning and getting things done) over the USDA healthy diet.
1 posted on 07/07/2024 6:59:57 PM PDT by ConservativeMind
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To: Mazey; ckilmer; goodnesswins; Jane Long; BusterDog; jy8z; ProtectOurFreedom; matthew fuller; ...

The “Take Charge Of Your Health” Ping List

This high volume ping list is for health articles and studies which describe something you or your doctor, when informed, may be able to immediately implement for your benefit.

Email me to get on either the “Common/Top Issues” (20 - 25% fewer pings) or “Everything” list.

2 posted on 07/07/2024 7:00:37 PM PDT by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
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To: ConservativeMind

I bet ice cream ain’t on the list...


3 posted on 07/07/2024 7:11:22 PM PDT by Red Badger (Homeless veterans camp in the streets while illegals are put up in 5 Star hotels....................)
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To: ConservativeMind
I think it was author Michael Pollan who said the optimal diet is to eat real food (not factory-produced crap), not too much, and mostly plant-based.

I don't think it's any more complicated than that.

4 posted on 07/07/2024 8:00:40 PM PDT by Lizavetta
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To: ConservativeMind

“intermittent fasting gave a 20% edge in memory and executive memory “

How would Brandon fare with intermittent fasting?

How about frequent fasting?

How about continuous fasting?

Or, what if he went all the way to PERMANENT fasting?


5 posted on 07/07/2024 8:06:59 PM PDT by ProtectOurFreedom (“When exposing a crime is treated like a crime, you are being ruled by criminals” – Edward Snowden)
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To: ConservativeMind
“This is a marker to continue to evaluate in further studies,” says Mattson. “Neurons release a lot of proteins, and one idea is that intermittent fasting may be causing some kind of neuroplasticity (a change in structure) in neurons, causing the release of neurofilament proteins.”


Fasting activates the autophagy regenerative process and has been shown to have very beneficial neuroprotective effects on the brain and nervous system.

Fasting or a fasting mimicing diet can be a very effective treatment for epilepsy and Multiple Sclerosis and other auto immune diseases.

It is also very effective at preventing dementia and managing other degenerative brain and nervous system diseases

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6836141/

Prolonged fasting of 14+ days has been shown to reverse epilepsy symptoms and even provide a complete cure in some patients.

Periodic cycles of on /off fasting consisting of 5-7 days of fasting stage to induce autophagy followed by a regenerative period ranging from several days to 4-6 weeks with a well controlled , preferably ketogenic diet is very beneficial for managing Multiple Sclerosis and has even been shown to initiate and promote re mylination in lab testing - the holy grail of MS research.

Similar fasting cycles combined with a ketogenic diet can also be effective in managing other neuro degenerative conditions like dementia and Huntington's disease by scavenging amyloid and other toxic protein accumulations that damage brain and nerve tissues during the fasting cycle followed by neuroplastic healing and regeneration during the non fasting phase of the cycle.

6 posted on 07/08/2024 4:36:51 AM PDT by rdcbn1
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To: ConservativeMind

Coming from the same folk who had the food pyramid upside down for generations.


7 posted on 07/08/2024 6:44:03 AM PDT by bgill (.)
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To: bgill

Who paid for the study?


8 posted on 07/08/2024 6:45:13 AM PDT by dfwgator (Endut! Hoch Hech!)
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