Study shows amino acids reduce acute kidney injury after cardiac surgery

Medical Xpress / HealthDay / New England Journal of Medicine ^ | June 18, 2024 | Lori Solomon / Giovanni Landoni et al

[ConservativeMind]

Among adult patients undergoing cardiac surgery, infusion of amino acids reduces the occurrence of acute kidney injury (AKI), according to a study published online.

Giovanni Landoni, M.D. and colleagues examined the efficacy of amino acids in reducing the occurrence of AKI after cardiac surgery. The analysis included 3,511 adult patients who were scheduled to undergo cardiac surgery with cardiopulmonary bypass who were randomly assigned to receive an intravenous infusion of either a balanced mixture of amino acids (2 g per kilogram of ideal body weight per day) or placebo (Ringer's solution) for up to three days.

The researchers found that AKI occurred in 26.9% of patients in the amino acid group and in 31.7% of the placebo group (relative risk, 0.85). Stage 3 AKI occurred in 1.6 and 3.0% of patients, respectively (relative risk, 0.56). Kidney replacement therapy was needed in 1.4% of patients in the amino acid group versus 1.9% in the placebo group. Secondary outcomes and reports of adverse events were found to be similar between the groups.

"These findings appear to be clinically and epidemiologically important because they may apply to more than two million patients who undergo heart surgery worldwide every year and because AKI is an independent risk factor for subsequent chronic kidney disease," the authors write.

[ConservativeMind]

They apparently used a balanced mixture, of what I am assuming, were essential amino acids. It seems to gave been put in their IV.

It reduced chance of acute kidney failure by 27%.

[ConservativeMind]

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[cpdiii]

The difference of 2 percent is not significant unless the study is of thousands of patients. The article did not mention the number of patients. It may be a good article of good science or not?

I had heart surgery, replacement of my aortic valve and proximal aorta. I had several units of blood given. Blood is full of amino acids. This article is most lacking in details. Without details of the procedure, and the patients this article is worthless though it may be correct which I suspect it is not.

[ConservativeMind]

Sorry, that relative risk shows it reduced it 15%, not 27%.