Posted on 06/06/2024 9:09:09 PM PDT by ConservativeMind
A recent study shows that there may be a more effective way to treat melanoma by using ascorbate (vitamin C) to increase DNA damage in cancer cells, leading to their death, according to Marcus Cooke.
The multi-disciplinary research team found that melanoma cells have more DNA damage and fewer antioxidant defenses compared to normal skin cells. When treated with hydrogen peroxide and vitamin C, melanoma cells showed even more DNA damage and higher cell death rates, while normal cells were protected. Additionally, the study results found that vitamin C boosted the effectiveness of an existing melanoma drug, elesclomol.
"We've been studying the effects of antioxidants since the late 1990s and have been fascinated by the ability of vitamin C to act as a prooxidant (causing DNA damage) and antioxidant (preventing DNA damage), and its apparent ability to help modulate DNA repair," Cooke said.
"The findings show that melanoma cells have higher levels of DNA damage than keratinocytes (the primary type of cell found in the epidermis). We discovered that this damage was proportional to the amount of melanin that is in the melanocytes—the more melanin, the more damage," he explained. "This is in cells not even exposed to sunlight, suggesting that melanin within cells can cause damage in melanoma cells."
Cooke acknowledges that additional clinical studies and trials would bolster these findings and assist in moving towards including ascorbate as an accessory in treatment.
"Given that ascorbate is already well studied and is known to be well tolerated, I think that clinicians could include ascorbate as an addition to existing treatment to enhance existing approaches if they act by inducing DNA damage as elesclomol does," he said.
(Excerpt) Read more at medicalxpress.com ...
Waiting for the next study to tell me the opposite.
So maybe Linus Pauling was right
is there such a thing as topical vitamin C? How does one apply it with H2O2?
I understand that vitamin C can simply be taken by mouth, but how is the hydrogen peroxide administered to in-vitro melanoma?
Topically?
I ask, because I’ve had two melanomas removed by surgery.
Don’t melanomas sometimes heal themselves and disappear?
Pauling and Cameron in the 1970s showed that intravenous C-vitamin increased survival rates in patients with terminal cancer. Their study was not placebo controlled, so when the Mayo Clinic published two placebo controlled studies that neither showed any effect the interest in use of C-vitamin in cancer treatment faded. The fact that the latter studies used only oral administration and for shorter periods was considered less important than the fact the studies originated from a very reputable institution and were placebo controlled.
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National Institutes of Health (NIH) (.gov)
https://www.ncbi.nlm.nih.gov › articles › PMC10688485 by DV Tran · 2024
"Additionally, it was found that the combination of dietary and supplementary vitamin C intake significantly increased the risk of lung cancer."
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Hydrogen peroxide fuels aging, inflammation, cancer ...
National Institutes of Health (NIH) (.gov)
https://www.ncbi.nlm.nih.gov › articles › PMC3180186 by MP Lisanti · 2011 · Cited by 250 — Summary:
"Hydrogen Peroxide in Tumor Initiation, Progression and Metastasis ... In summary, hydrogen peroxide is a known carcinogen, and is....."
In conclusion, in the present meta-analysis of cohort studies it was found that the dietary intake of vitamin C is beneficial for the prevention of lung cancer, whereas its supplementary intake does not have any beneficial effect. The findings of the present study should be confirmed by further prospective studies and RCTs.
"should be confirmed by further prospective studies and RCTs."
Thanx for posting this
The multi-disciplinary research team found that melanoma cells have more DNA damage and fewer antioxidant defenses compared to normal skin cells.
The reason that radiation therapy is effective with cancer is that cancerous cells are less capable of repairing DNA damage than normal cells. The radiation induces extensive DNA damage. Cancer cells die and normal cells repair themselves (or decide to die also).
When treated with hydrogen peroxide and vitamin C, melanoma cells showed even more DNA damage and higher cell death rates, while normal cells were protected. Additionally, the study results found that vitamin C boosted the effectiveness of an existing melanoma drug, elesclomol.
Normal cells are not resistant to hydrogen peroxide (H2O2). It is difficult to imagine how H2O2 could be administered to an intact patient without having all kinds of toxicity issues. It might be beneficial to make sure patients get adequate vitamin C during chemotherapy--but trying to load up their bodies with excess vitamin C is likely to be a futile approach, since their kidneys will be working to remove all excess vitamin C.
A few citations on this thread by NIH. During Covid, we learned that that organization has corrupt leadership, and is in bed financially with drug companies. Since then, it’s hard to put much faith in anything they say or do.
“Vitamin C with hydrogen peroxide appears to help kill melanoma cells.”
If it’s cheap and simple they’ll never approve it.
Food Grade Hydrogen Peroxide Can be Used AS a Mouthwash and Swallowed
There is . You can look it up. I would think orally as well With Food Grade Hydrogen Peroxide
Food Grade Hydrogen Peroxide Can be Used AS a Mouthwash and Swallowed”
Food Grade Hydrogen Peroxide Shouod not be Used AS a Mouthwash and Swallowed
“Vitamin C with hydrogen peroxide appears to help kill melanoma cells.”
If you suspect melanoma DO NOT SELF TREAT!
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