Posted on 04/17/2024 5:16:44 PM PDT by DoodleBob
Wednesday, GSK plc (NYSE:GSK) revealed data from the ZOSTER-049 long-term follow-up phase 3 trial, which followed participants for up to approximately 11 years following initial vaccination with Shingrix (Recombinant Zoster Vaccine or RZV).
The final trial data demonstrate that RZV has maintained efficacy against shingles in adults over 50 for over a decade.
ZOSTER-049 included over 7,000 participants.
The results from ZOSTER-049, an extension from two phase 3 clinical trials in adults aged 50 and over (ZOE-50 and ZOE-70), include:
79.7% vaccine efficacy (VE) in adults aged ≥50 cumulatively from year six to year 11 after vaccination.
82.0% VE in adults ≥50 at year 11, showing VE remains high each year after vaccination.
73.1% VE in adults aged ≥70 cumulatively from six to 11 years after vaccination, showing high VE rates across all age groups.
Javier Díez-Domingo, Principal Investigator, said: “These final data demonstrate continued protection over more than a decade with high efficacy maintained in both the 50+ and 70+ age groups.”
GSK said it will continue to evaluate long-term data and conduct real-world evidence studies on vaccine efficacy, immunogenicity, and safety across indicated populations.
No new safety concerns were identified during the follow-up period in ZOSTER-049.
The investigators considered no serious adverse events causally related to RZV vaccination.
In adults aged 50 years and over, the most frequently reported adverse reactions with RZV are pain at the injection site, myalgia, fatigue, and headache. Most of these reactions were mild to moderate in intensity and generally lasted less than three days.
(Excerpt) Read more at msn.com ...
That’s pretty awesome.
And now, in this corner, the shots for covid…for BNT162b2 [Pfizer–BioNTech], mRNA-1273 [Moderna], ChAdOx1 nCoV-19 [AZD1222; Oxford–AstraZeneca], and Ad26.COV2.S [Janssen]):
https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(23)00015-2/fulltext
…VE against Omicron was 32% at 140–167 DAYS after injection.
Yes, the Covid bug mutates. Therefore, don’t tell us that the Covid shot, at 96% VE in late 2020 on a curated group of 40,000 people in a trial run for a few months,, will stay at 96% as a preventative thing for a long time.
Many of us aren’t antivaxxers….we simply distrust charlatans.
“But boostahs ALWAYS were neeeeded!”. - jab pushers conventiently forgetting that cowpox provided permanent immunity to smallpox.
Do you know what the percentage is for people who had chickenpox as a child?
So, is this new vax based on mRNA tech? If so, I’ll pass. I’ll probably pass anyhow, as I’ve developed serious trust issues since 2020.
How long til this shot has the other shot in it?
I had chicken pox as a kid. Im 61 this year. Its on the radar screen and moving fast.
I do not think so. It was developed and marketed well before the COVID19 hoax.
If you trust the CDC...
https://www.cdc.gov/shingles/about/index.html
About 1 in every 3 people in the United States will have shingles in their lifetime.
If you had chickenpox, you are at risk for shingles.
More than 99% of Americans born before 1980 had chickenpox, even if they don’t remember it.
Who told us that? It was known very early on that COVID mutated at least as fast as flu viruses. The simple fact of it being a coronavirus would have lead me to guess mutation would be even faster than for most flus.
Yes. Chickenpox was considered an almost mandatory childhood disease when I was growing up.
Don’t know that either. All I know is I had chickenpox.
It’s rather easier to do a 10 year measurement if a disease has been around for 10 years.
“ Shingrix [Herpes Zoster vaccine (recombinant, AS01B adjuvanted)] is a non-live, recombinant subunit vaccine which combines a recombinant antigen, glycoprotein E and the adjuvant system, AS01B”
Full disclosure: I don’t work for GSK nor do I have anything to gain from Shingrix’s success.
Ping - Zoster Vax
I have a friend who got Shingles in her 80’s. She said the pain was so bad she wanted to die. It lasted for months.
I read somewhere that Ivermectin is effective against Shingles. I’ll try that instead.
Will be 62 this year. Last year my doctor said I was due for tetanus, flu, COVID & shingle shots. Told him I had two arms & I wasn’t taking the COVID. Landed on tetanus and the shingle. Not sure which one they gave me but I had two of them over the course of a couple weeks. Second one sucked for a couple days but I knew people that had shingles & told horror stories. One lady got them in her eyes.
Shringrix has adjuvants. Additives that irritate tissues and cause inflammation, which seems to be necessary to provoke a strong immune response. That additional efficacy with inflammation is why back in the day your smallpox vaccination was made with a little forked needle to make a good welt.
The problem is chemical adjuvants can make you develop an immune system reaction to random other self tissues. Autoimmune diseases can take years to emerge, are difficult to identify and diagnose, and almost never have a root cause proven.
I get shingles outbreaks but so far just a few itch areas and blisters. But I dread autoimmune diseases. So I refuse Shingrix.
They gave a lot of soldiers in Gulf War 1 an experimental anthrax vaccine loaded with em,then later denied the vets medical benefits for Gulf War Syndrome was because the diseases they ended up with did not fit a simple symptom list.
One big reason adjuvants are used is to lessen the amount of antigen need to get a good reaction, so the vaccines are cheaper to manufacture.
I’m not an antivaxer either but I am very wary of adjuvants. Actually some of the problems with MRNA vaccines may also have to do with adjuvants. Some people think that there is graphene in some of them as an adjuvant.
I’ve heard the shingles vaccine can come with some pretty unpleasant and persistent side effects.
If shingles is caught very early on, within the first two days, there is an antiviral medication they can give you for it that significantly lowers the severity of the disease.
I react very poorly to immunizations to begin with and have seen what shingles looks like, so I am conscious of the need to seek immediate treatment if I get the blisters and I suspect shingles.
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