[ConservativeMind]

It appears oxidized LDL is quite instrumental in the destruction of our back discs. Minimizing LDL and/or oxidized LDL, could be helpful.

From the published paper:

“The presence of ox-LDL and LOX-1 was positively related with the extent of IVDD in nucleus pulposus (NP), end-plate cartilage and outer annulus fibrous, but not with the extent of degeneration of inter annulus fibrous. Ox-LDL significantly reduced the viability of human NPCs in a dose and time-dependent manner, and increased the expression of MMP3 induced by LOX-1. Pretreatment with anti-human LOX-1 monoclonal antibody reversed these effects. Ox-LDL, principally mediated by LOX-1, enhanced MMP3 production in NPCs through the NF-κB signaling pathway. In conclusion, increased accumulation of ox-LDL and LOX-1 in IVDs indicates a specific role of the receptor- ligand interaction in degeneration or herniation of IVDs.”

[ConservativeMind]

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[ConservativeMind]

Additional information from the paper:

“Epidemiological studies have concluded that hyperlipidemia and atherosclerosis were related to intervertebral disc degeneration (IVDD).”

[Magic Fingers]

That doesn’t appear to bode well for carnivore/keto dieters.

[MikelTackNailer]

How about a person like myself who's vertebrae degenerated from the radiation and chemotherapy used to defeat cancer? Despite careful application destroying the disease I still ended up "extra crispy" instead of "traditional recipe", finding the bone structure no longer able to support weight.

The VA and Vanderbilt Medical installed an amazing titanium skeletal support structure that's surpassed expectations so much I'm OFF disability and working full time again. Which makes me an idiot - but the work pays better than disability and I can't stand uselessness.

So my laymen question is 'How does this new insight about cellular oxygen usage actually help people?' or is this yet another paper from people trying to publish over perish?

And why DO you post so many medical articles that are obviously geared to those far more specialized in your field than most people here can comprehend? Is it some sort of ego validation thing for your personal benefit or what?

I strive for the opposite, trying to make the complicated understandable to most people in a way that garners their further interest rather than make them feel stupid.

[Bigg Red]

mark

[jcon40]

I don’t see in the article if “concentrated Oxygen” is the same as the Ozone (therapy) I’ve been reading about for IVDD on google scholar.

Is concentrated oxygen the same as ozone ?