Posted on 12/09/2023 11:38:26 AM PST by ConservativeMind
Almost a third of people with fatty liver disease go on to develop an advanced form of the disease, known as non-alcoholic steatohepatitis (NASH) that can progress to cirrhosis and end-stage liver disease, or even liver cancer, and is a major risk factor for cardiovascular disease.
Why some people remain relatively healthy with fatty liver disease and some go onto potentially life-threatening illness has been a mystery. Until now.
A study has shown that the levels of the NOX4 protein change as the disease progresses—rising in the early stages of the disease to protect the liver, but declining as the liver disease gets worse.
According to Professor Tiganis, the precise mechanisms that govern the transition to NASH and liver damage have remained unclear.
"It has been perplexing why the majority of patients with fatty liver disease don't progress to more severe disease," he said.
The researchers have shown that this is because NOX4 is induced when the liver first starts to accumulate fat and activates a complex adaptive program that protects the liver. It is only when NOX4 levels decline and this adaptive program is abrogated that obese patients with fatty liver progress to NASH and liver damage.
Importantly, previous studies by Professor Tiganis and others have shown that the raising of NOX4 levels in skeletal muscle or in the heart after exercise protects against damage, promotes muscle and cardiac function and prevents the metabolic decline otherwise associated with aging.
"Compounds that bolster the activity of NOX4, or the adaptive program that NOX4 instigates, may be highly beneficial, countering not only the development of NASH, but also improving skeletal and cardiac function, as well as metabolic health," Professor Tiganis said.
Such compounds are found naturally in cruciferous vegetables, such as broccoli or cauliflower.
(Excerpt) Read more at medicalxpress.com ...
By the way, a prior small study showed pantethine could reverse fatty liver in over half of patients, in just six months.
The effects of pantethine on fatty liver and fat distribution (56% study participants eliminated fatty liver in six months)
https://freerepublic.com/focus/f-chat/4008349/posts
Don’t drink alcohol and don’t drink sugary beverages. You’ll never have a fatty liver.
Bkmk
CM Thanks for posting this info!
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