Turning back the clock on brains aged by COVID-19 (Fisetin and quercetin may help)

Medical Xpress / University of Queensland / Nature Aging ^ | Nov. 22, 2023 | Julio Aguado et al

[ConservativeMind]

University of Queensland researchers have found a way to reverse a cellular process triggered by COVID-19 that contributes to premature aging of the brain.

Dr. Julio Aguado and a team used synthetic brain organoid models, grown in a laboratory from human stem cells, to study the effect of different SARS-COV-2 variants on brain tissue.

"We found COVID-19 accelerates the presence of 'zombie' or senescent cells, which accumulate naturally and gradually in the brain as we get older," Dr. Aguado said. "Senescent cells are known to drive tissue inflammation and degeneration, leaving patients exposed to cognitive impairments like brain fog and memory loss."

Dr. Aguado said confirmation that COVID-19 was a catalyst for this premature aging prompted an attempt to reset the biological brain clock.

"We used the brain organoids to screen a range of therapeutics, looking for any capable of removing those senescent cells," he said.

The researchers found four drugs that selectively eliminated the cells caused by COVID-19—navitoclax, ABT-737, fisetin and a cocktail of dasatinib plus quercetin (D+Q).

Dr. Aguado said the drugs rejuvenated the brain and decreased the chance of neurodegenerative symptoms in the organoids, as well as in a mouse model infected with COVID-19.

"More research is needed to fully understand the mechanisms at play, but this study marks a significant step forward in our knowledge of the intricate relationship between viral infections, aging and neurological well-being," he said. "Long term, we can expect widespread use of these drugs to treat persistent post-acute infection syndromes caused by viral infections like COVID-19."

[ducttape45]

This is what I take now, via One A Day multivitamin and a D3 and Niacin supplement

Zinc, 11 mg
Vitamin A, 900 mcg
Thiamin (B1), 1.32 mg
Riboflavin (B2), 1.43 mg
Niacin, 500 mg
Vitamin B6, 2.17 mg
Vitamin B12, 6.24 mg
Vitamin C, 99 mg
Vitamin D3, 2000 IU
Vitamin E, 15 mg
Calcium, 210 mg
Iron, 0 mg
Iodine, 150 mcg
Magnesium, 120 mg
Selenium, 55 mcg
Copper, .9 mg
Manganese, 2.3 mg
Chromium, 35 mcg

Dang, forgot the breaks

[Georgia Girl 2]

I would double the D3 and take K2 with it.