Posted on 08/13/2023 6:06:40 PM PDT by definitelynotaliberal
This is just a modified limited hangout.
Genetic testing has been too hard to get. Even now insurance companies don’t want to pay for it for P450 issues.
There is absolutely no doubt in my mind that many people have the issue and have no clue.
A p-glycoprotein issue causes an issue with ivermectin crossing the blood brain barrier. If it can cause it with that drug it certainly could do it with other drugs.
This is really an evolving state in medicine. For example..they have just really started indicating plaquenil could be an issue for people with p450 problems
My advice is if you have had problems with a drug ..get the whole genome test. Don’t rely on Doctors to figure it out. A good place to look to see how drugs are metabolized and what could interact even if you have no genetic issues is the drug bank website.
Here is an example. Parkinson and alzheimers have been possibly linked to a Cyp2d6 issue. Of course I am sure there are other issues. It would be interesting to know if Michael j fox has the genetic fault in cyp2d6. Cyp2d6 is one of the big enzymes used in drug processing but because it also helps clear toxins in the brain a faulty gene makes you susceptible. One faulty gene from one parent is enough to cause a problem but if you get it from both you could have ZERO functioning Cyp2d6
The problem is not just overdosing. It is what happens to your brain if it crosses the barrier. Too much still unknown. Is it only people with a genetic defect that it happens to..or is it a drug combination..or did they have a problem because fatty foods increased toxicity.
https://www.nejm.org/doi/full/10.1056/NEJMc1917344
So take my case. I have similar genetic issue that border collies have who have a problem with ivermectin. If I got one of the parasite diseases should I take full dose..or full dose of a covid preventative..or full dose if I got covid....
If I took a full dose as a preventive it might not kill me but it could creep into my brain and screw me up for alzheimers down the road
People should make informed decisions..not just fly by the seat of their pants thinking ivermectin is safe for everyone. I have taken ivermectin but no where near full dose
Btw..I know full well that so far every single one of my doctors has been clueless on how to deal with my genetic drug issues.
This does not mean that very few people in the world have my problem. It means they just haven’t been genetically tested.
Here is another way to think about this...if you take too much ivermectin the pumps get overwhelmed and can’t pump it out so it crosses brain barrier...
But the same thing can happen if you have genetic mutations that cause problems with the pumping..like I have.
How rare are these mutations...who knows.but given how not one single doctor thought to check me for drug mutations I would say more common that scientists know.
And now that we know I have PAGES of drug mutations genes..no Doctor I have has dealt with them before.
I am disgusted with the medical paradigm
I’ve had it work very well for colds and flues though. I had one flu that zapped my strength and before I went to bed, I took it- nose running, headache, fever, shivering etc. 2 hours later I woke up almost as though I had never had the flu. (I was still a little run down on strength, but fever was gone, chills, etc). My folks who are quite elderly now also take it and I’ve seen th3m sick in the morning, take a dose, and by afternoon look and feel much better.
I am taking the vet stuff though as the pills got outrageously expensive and docs stopped prescribing it under “suggestions”/orders from fdc.
Here is another potential issue..say you have no genetic defect but you are taking big doses of vitamin A And E
https://cdnsciencepub.com/doi/abs/10.1139/cjpp-2023-0078
LOL, yup. We have some liberal family visiting us this week, and we are trying desperately to keep from discussing anything political or related to covid BUT they keep bringing it up- however, when we try to I terject some common sense, they will get angry and say something along the lines of “oh we don’t listen to a.ternative facts” or some such nonsense.
They go on and on about how they still wear masks to this day in certain situations and let us onow that they are “good concerned citizens” for doing so! Ugggh! You just can’t argue with irrationality like that- they are STILL scared to death of covid!
Clint Eastwood said “If you could reason with liberals, there wouldn’t be any liberals” lol. How right he is!
Btw..that study has ramifications for other drugs that are p gp substrates.
Drug bank lists a predictor tool that MRI contrast is one...chuck Norris wife may have had a genetic issue that caused her problem with MRI contrast
Very good points! Most of those that were actually hospitalized were done so because their cases had advanced beyond simple “home remedies” and care (hospitals sent oodles of people home telling them to monitor their health, and if they developed trouble breathing, to go back to hospital. They essentially sent the majority home telling them to take Tylenol and just “watch and wait”- for those folks, ivermectin may have worked wonders and kept them from developing into full blown lower respiratory covid cases like you mentioned.
Once the cytokin storm hits hard, the outlook wasn’t so good, and ivermectin would never have been enough, especially on its own or in co junction with antibiotics
Also, I don’t know if it’s true or not, but there were sites saying it needed to be taken with zinc to be the most effective? We did take it with zinc just incase that was true. But if it is true, I doubt the hospitals were administering zinc along with it?
Do you I crease your vit D when you think a virus is coming on? I’ve read that megadosing can help- (50,000 to 80,000 iu). I’m not sure if that is true either, if so, it’s a cheap way to gain extra help when sick
[[Not only did they lie & intentionally kill untold numbers of people, they cashed in and got rich at the same time]]
I’ll also add, “and they looked the pub,ic in the eye and dared them to do anything about it, knowing that they could destroy the lives of anyone that tried!”
[[...if you take too much ivermectin the pumps get overwhelmed and can’t pump it out so it crosses brain barrier]]
Any idea rpughly at what dose that happens at? (For people without the genetic defect?)
This is an area that is so understudied
Imo...if you are going to assume you have no genetic problem...and you want to take the dose reccommended by that group that advocates for it. .then be darn sure you take it on an empty stomach and with no other things that might cause it to cross the brain barrier..like vitamin a and e..
To me the risk is what it does while In your brain...of course if you are already on your deathbed because of covid you won’t care about that..you aren’t going to care if you might get long term neuropathy from it
The other thing that so many people advocate is quercetin. But you better look at all the things quercetin inhibits and interacts with. You can look it up on the drug bank website
And I will say again...I will bet many of you here have drug genetic problems..there are a lot of them...so if you have had a problem with a drug or drugs don’t work like they should spend the money and get a whole genome test. I am in the last decades of my life and no one ever thought to test me.
Drugs are a crap shoot anyway for people with no defects
EUA is based on the concept that their is no other alternative treatment. Thus the EUA should be removed.
Yeah ive seen the quercetin interactions and side effects- I take ECGC? (NOT SURE I have the spelling right- it’s basical.y green tea extract) which seemed to have less adverse possibilities.
The possible alzheimer’s risk though is concerning for ivermectin- not sure though how much of a risk it is.
They’re (the self-anointed elites) also ignorant, very ignorant and gullible. Most seem to present the Dunning Kruger effect.
For sure.
They should be imprisoned for manslaughter for the deaths they caused by using propaganda against Ivermectin.
ALZHEIMER’S risk is really about the CYP2d6 issue not clearing out the neurotoxins.
Ivermectin would be put in the category in my opinion of any drug potential problem that crosses the blood/brain barrier that is not suppose to cross..
So it would go like this...if a drug is known to cause neurotoxin issues if it manages to cross the barrier then it could be a risk. Way too much is unknown about brain diseases.
And if on top of that you have an enzyme issue in the brain whereby it doesn’t adequately clear neurotoxins you then have an additional problem
Disclaimer: Opinions posted on Free Republic are those of the individual posters and do not necessarily represent the opinion of Free Republic or its management. All materials posted herein are protected by copyright law and the exemption for fair use of copyrighted works.