Here is another potential issue..say you have no genetic defect but you are taking big doses of vitamin A And E
https://cdnsciencepub.com/doi/abs/10.1139/cjpp-2023-0078
Btw..that study has ramifications for other drugs that are p gp substrates.
Drug bank lists a predictor tool that MRI contrast is one...chuck Norris wife may have had a genetic issue that caused her problem with MRI contrast