The next best algorithm, the Sampson, has a prior study showing it was best used with high triglyceride people (and more accurate than Martin/Hopkins with those individuals), but this study is showing the formulas are neck-and-neck for accuracy and enough better than the normal Friedewald method to make it worth plugging in your numbers to get a likely more accurate LDL number for you. The Sampson formula is not proprietary and is free for all use.
What was really nice was the original paper (free) has a supplement file that gives you the formulas. I’ll post that link, next.
The study supplement, with the formulas (including Sampson):
https://storage.googleapis.com/jnl-up-j-gh-files/journals/1/articles/1214/6490448c661fc.pdf
The Excel spreadsheet for non-commercial use (appears to be free to use by doctors and patients, but not for sale purposes):
#1 there 5 different kinds of LDL chloresterol and only the small dense small particle is one of any demerit.
#2 The HDL and triglyceride count is a much more accurate picture of blood health.
#3 Chloresterol was a non factor before the 70's when Big Pharma found a way to lower LDL chloresterol (the larger fluffier benign kind). Now the AMA and every doctor is a sales rep for Pfizer to sell statins.
#4 Smoking, obesity chronic inflamation (from 2 diabetes and metabolic syndrome and hypertension are much more risk factors for Cardiac problems than chloresterol.
Associate research is the lowest level of research and one cannot reliably base a prognosis or any conclusion on it alone.
bttt
AGAIN. LDL cholesterol is not a problem. Neither is HDL cholesterol. Both are required in abundance for human life.
The only bad cholesterol are CLDL cholesterol, and they are not really cholesterol at all. CLDL cholesterol are dead shells of cholesterol which a glycated liver fails to fill with acetone. This failure comes when the patient consumes a diet too rich in fructose (anything which tastes sweet).
The differences between people’s LDL-to-HDL ratios are caused by inborn APoE genetics and mean very little to health outcomes.
When a liver fails to fill cholesterol particles it leaves the unused acetone in the bloodstream as “triglyceride”. Have your triglyceride levels checked if you suspect a problem.