Direct oral anticoagulant therapy found to be feasible for cancer patients

Medical Xpress / HealthDay / JAMA ^ | June 6, 2023 | Lori Solomon / Deborah Schrag et al

[ConservativeMind]

Direct oral anticoagulant (DOAC) treatment is noninferior to low-molecular-weight heparin (LMWH) for preventing recurrent venous thromboembolism (VTE) in cancer patients, according to a study.

Deborah Schrag, M.D. and colleagues assessed the effectiveness of DOACs (335 patients) versus LMWH (336 patients) for preventing recurrent VTE in patients with cancer (any invasive solid tumor, lymphoma, multiple myeloma, or chronic lymphocytic leukemia) over six months.

The researchers found that rates of recurrent VTE were 6.1 percent in the DOAC group versus 8.8 percent in the LMWH group (difference, −2.7 percent), consistent with the prespecified noninferiority criterion.

None of the six prespecified secondary outcomes were significantly different between the groups. Major bleeding did not meet the noninferiority criterion, as it occurred in 5.2 percent of the DOAC group versus 5.6 percent of the LMWH group (difference, −0.4 percent; 1-sided 95 percent confidence interval, –100 percent to 2.5 percent). Severe adverse events occurred in 33.8 percent and 35.1 percent of the groups, respectively. Anemia and death were the most common serious adverse events reported.

"These findings support use of a DOAC to prevent recurrent VTE in patients with cancer," the authors write.

[ConservativeMind]

Oral blood thinners appear to work as well as a common injectable, for cancer.

[ConservativeMind]

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