Low dose colchicine associated with lower incidence of total knee and hip replacements (Just .5 mg a day)

Medical Xpress / American College of Physicians / Annals of Internal Medicine ^ | May 29, 2023 | Michelle W.J. Heijman, MSc et al

[ConservativeMind]

An exploratory analysis of the LoDoCo2 (Low-Dose Colchicine 2) randomized, controlled, double-blind trial found that daily therapy with a low dose of colchicine was associated with lower incidences of both total knee replacement and total hip replacement surgeries.

Osteoarthritis is an increasingly common joint disease that can be associated with low-grade inflammation in response to weight-bearing traumatic injury. Previous studies have demonstrated an association between the use of anti-inflammatory therapies and the slowing of osteoarthritis disease progression. Colchicine is effective in many inflammatory and fibrotic conditions, but it is not currently recommended for treatment of osteoarthritis. Its long-term effects have also not been assessed.

Researchers conducted an exploratory analysis of the LoDoCo2 trial to examine whether colchicine, 0.5 mg daily, reduced incident total knee replacements and total hip replacements. In the study, 5,522 participants aged 35 to 82 at 43 centers in Australia and the Netherlands, received 0.5 mg of colchicine daily or matching placebo during a median follow-up of 28.6 months.

The authors found that 2.5 percent of persons receiving colchicine had total knee replacement or total hip replacement compared with 3.5 percent of persons who received placebo. The effects were consistent for men, but there was insufficient statistical power to determine whether these benefits may have extended to women as well. According to the authors, the exploratory observations support the hypothesis that inflammation plays a role in the progression of osteoarthritis.

They also note that colchicine has been widely used in many patients with other diseases and is generally considered to have a favorable safety profile, which makes it a good candidate for treatment of osteoarthritis over longer periods.

[ConservativeMind]

Colchicine is commonly available and not expensive.

[ConservativeMind]

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[SubMareener]

Get rid of the High Fructose Corn Sirup in your life, for starters. Shop the outer ring at the grocery store. Stay away from the aisles. Five years ago my wife was told she would need a knee replacement, and that nothing could be done to reverse her arthritis in that knee. We cut the dirty carbs, upped the fat and protein, and her knee is now no trouble at all.

[Yo-Yo]

Colchicine is a gout treatment.

[poinq]

We did the same. Wife and I lost a lot of weight and now joints all feel fine. In fact everything is better. But doctors keep recommending the SAD diet.

[SubMareener]

They call it SAD for a reason. I just had a physical, and they asked me if I was on a “low salt” diet. I said no, but now I realize that since I don’t eat oversalted processed food, I really am on a “low salt” diet.

[faucetman]

p

[dennisw]

MSM and sodium ascorbate will do the trick. Powders not capsules.
https://www.bing.com/search?q=MSM+and+sodium+ascorbate&PC=U316&FORM=CHROMN

[tired&retired]

Colchicine works by decreasing inflammation via multiple mechanisms.

Colchicine, in the form of the autumn crocus (Colchicum autumnale), has been used as early as 1500 BC to treat joint swelling. It was approved for medical use in the United States in 1961. It is available as a generic medication. In 2020, it was the 241st most commonly prescribed medication in the United States, with more than 1 million prescriptions.

Colchicine is widely used in plant breeding for inducing polyploidy, where the number of chromosomes in plant cells are doubled. This frequently results in larger, hardier, faster-growing, and in general more desirable plants than the normally diploid parents.

[GaltAdonis]

Apparently Colchicine is kind of hard on the kidneys - so do you research, folks.

"The plant source of colchicine, (is) the autumn crocus..."

Pretty flower...

[GaltAdonis]

"... now I realize that since I don’t eat oversalted
processed food, I really am on a “low salt” diet."

.

I've always watched my salt intake.
A month ago my blood work results came back from my check-up
and my sodium levels are TOO LOW.

I'll start adding some more salt to the soup or popcorn or whatever...