Tens of thousands of lives a year could be saved by new treatment protocol for brain hemorrhage (Quick correction of blood pressure)

Medical Xpress / George Institute for Global Health / The Lancer ^ | May 25, 2023 | Dr. Lili Song et al

[ConservativeMind]

Data from the phase III INTERACT3 study demonstrate that a new combination of treatments for stroke due to intracerebral hemorrhage (ICH) significantly improves the chances of surviving without major disability.

The INTERACT3 study is the first-ever randomized controlled trial to show a clearly positive outcome for the treatment of ICH. Timely administration of the new treatment protocol—known as a Care Bundle—centered on the rapid control of high blood pressure, led to improved recovery, lower rates of death, and better overall quality of life.

Professor Craig Anderson said, "Despite the high rates of ICH and its severity, there are few proven options for treating it, but early control of high blood pressure is the most promising."

Commonly referred to as a hemorrhagic stroke or brain bleed, ICH is the second most common type of stroke and also the most deadly, with 40% to 50% of patients dying within 30 days. It occurs when blood leaks out of a blood vessel into the brain tissue and represents over a quarter of all cases of stroke, affecting approximately 3.4 million people a year.

The research team evaluated the effectiveness of the new Care Bundle, which included early intensive lowering of systolic blood pressure, strict glucose control, fever treatment, and rapid reversal of abnormal anticoagulation.

They found that using this new treatment protocol was estimated to prevent one additional death for every 35 patients treated.

Central to this was a rapid reduction in systolic blood pressure, where target levels were achieved, on average, in 2.3 hours (range 0.8 to 8.0hrs), compared to 4.0 hours (range 1.9 to 16.0hrs) in the control group. The interventional protocol resulted in a statistically significant reduction in mortality, number of serious adverse events, and time spent in hospital, as well as demonstrating an improvement in health-related quality of life.

[ConservativeMind]

Quickly getting blood pressure and a few other health indicators under control made a difference in the death and complication rate.

[ConservativeMind]

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[Eccl 10:2]

Bloodletting?

[Does so]

“Despite the high rates of ICH and its severity, there are few proven options for treating it”

I treated ICH with methylene blue...