Posted on 05/25/2023 4:22:01 PM PDT by ConservativeMind
Scientists found that microbe fragments called endotoxin enter the blood stream and directly impact how well fat cells function, including their capacity to be metabolically active.
The normal gut contains microorganisms that have essential roles in human health. In obesity, however, the wall of the gut can become impaired and leaky, allowing release of these bacterial fragments into the blood, where they go on to travel through the body to different tissues.
Dysfunctional body fat is known to contribute to metabolic disease, including type 2 diabetes.
Using a series of experiments they found that fat cells are significantly damaged by endotoxin—and this reduced their ability to transform into more metabolically-active brown-like fat cells, which drive weight loss.
The study also found that white fat cells derived from participants with obesity were less likely to transform into brown-like fat cells compared with fat cells from lean individuals, likely due to the higher levels of endotoxin found in the blood of participants with obesity.
The team also examined how weight loss could reverse the circulating gut-derived endotoxin and resulting fat cell damage.
They found that weight loss surgical intervention, such as bariatric surgery, reduced the amount of endotoxin in the blood, which was also associated with improved metabolic health of the fat cells across the participants studied.
"Gut microbe fragments that enter the blood stream reduce normal fat cell function and their metabolic activity, which is exacerbated with weight gain, contributing to increased diabetes risk," said Professor Mark Christian.
He said, "It appears that as we gain weight, our fat stores are less able to limit the damage that gut microbe fragments may cause to fat cells. Endotoxin from the gut reduces fat cell metabolic activity and its ability to become 'brown-like fat cells' that can be useful to help lose weight.
(Excerpt) Read more at medicalxpress.com ...
This is reversible by losing fat weight.
bkmk
RE: This is reversible by losing fat weight.
Tell it to my thyroid. (low thyroid with levothroxine taken daily).
Also each decade older the same weight loss targets become more elusive.
I watched the last hour or so of The Truth About Fat on PBS.
It interviewed the Biggest Loser victorious subjects——all after they had regained all the fat plus more about 3 years later.
Scary show. The body keeps plotting to discover what you are doing and undermine you to keep you fat so you won’t die in the caves again as in the earlier ice age days. Cave people with weight gain genes survived to have children to pass the bad news onto all of us. “Set point” adjusts so more exercise and less eating result in more new fat pounds added.
or.. they could stop cramming food in their mouths!
I’ve recently discovered a strange trick to losing weight: make sure your caloric expenditures exceed your caloric intake.
That's their stories and they are sticking to it.
-s
“make sure your caloric expenditures exceed your caloric intake”
Spoken like someone who has never studied biology, physiology, or pretty much anything to do with human metabolism.
The only thing that simplistic approach accomplishes is to permanently degrade your baseline metabolism...
It’s a bit more complicated than that.
These researchers are idiots as well:
“They found that weight loss surgical intervention, such as bariatric surgery, reduced the amount of endotoxin in the blood, which was also associated with improved metabolic health of the fat cells across the participants studied.”
This is like a miner finding gold and discarding it as pyrite.
They literally discover the key to reversing metabolic disease and they can’t see the solution staring them in the face.
smh
Did your studies include physics?
They found that weight loss surgical intervention, such as bariatric surgery, reduced the amount of endotoxin in the blood
~~~~~
“Leaky gut” happens in the ileum, just after the stomach. Replace the top few inches, and digestion starts happening without leaky gut again. However, without a change in diet the new section of upper ileum becomes just porous as the old section.
bump
Yes. I studies physics and engineering during my career after graduating with a degree in Biology.
The vast majority of calories are burned through resting metabolism.
Eating less and exercising more more often than not reduces resting metabolism, such that what you would likely consider a ‘calorie deficit’ will just become a new metabolic equilibrium at the same body weight. It also triggers food cravings.
Two very good women friends of mine both eat far less than I do, and exercise far more than I do, but because they have a different endocrine system and have tried for years using calorie reduction, they are no longer achieving results.
Both of them could kick your ass too, but that’s a different story.
You really don't know whom you're talking to.
People need to undergo a period of training BEFORE bariatric surgery, and their change in lifestyle must be permanent.
You don’t seem like the type of person worth knowing, so I’m fine with it.
Ouch.
At which point the caloric intake must be reduced further.
No matter how efficient the body becomes, reducing the caloric intake below the caloric requirements will result in weight loss. Period.
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