Posted on 05/18/2023 8:47:22 PM PDT by SeekAndFind
Vaccine developers at the National Institute of Allergy and Infectious Diseases (NIAID) are enrolling healthy adult Americans to test an experimental universal influenza vaccine using mRNA technology.
The Phase 1 trial will be conducted at Duke University in Durham, North Carolina, the NIAID said on Monday. Researchers will test the experimental vaccine, dubbed H1ssF-3928 mRNA-LNP, for safety and its ability to induce an immune response.
For this early-stage trial, the federal research agency is looking for up to 50 healthy volunteers aged 18 through 49. There will be three 10-participant groups receiving 10, 25, and 50 micrograms of the experimental vaccine, respectively. After evaluation of the data to determine an optimum dosage, an additional 10 participants will be administered with the optimum dosage.
The study also will include a group of participants to receive a currently available flu vaccine that protects against the four most common flu virus strains in circulation.
The NIAID said it expects to collect all the data needed by March 15, 2024, and conclude the study by Aug. 30, 2024.
The name H1ssF is an abbreviation of H1 hemagglutinin stabilized stem ferritin, meaning that the vaccine uses the “stem” part of the influenza hemagglutinin protein displayed on the surface of a ferritin nanoparticle as the immunogen. The “stem” remains largely unchanged throughout influenza mutations, as compared to the “head,” which constantly changes as the virus mutates into different strains in a process called “antigenic drift.”
Most of the body’s immune response to the influenza virus is directed toward the ever-changing “head” of the hemagglutinin protein, and hence seasonal influenza vaccines must be updated each year. NIAID researchers believe that a vaccine that targets the “stem” without the distraction of the “head” could offer stronger and longer-lasting immunity.
The other part of the experimental vaccine’s name, mRNA-LNP, means that the messenger RNA-encoded immunogen is delivered inside a lipid nanoparticle (LNP). The vaccine doesn’t contain the immunogen, but uses LNP-coated mRNA to instruct the host cells to assemble the immunogenic proteins that can trigger the production of effective antibodies.
The same mRNA technology is used to make both Pfizer-BioNTech and Moderna COVID-19 vaccines, two of the most administered vaccinations in the world. Despite their widespread use, championed by governments of many countries under the premise that the shots are safe and effective, the mRNA vaccines continue to spur concerns about serious side effects, including a heightened risk of cardiac-related deaths in healthy teenagers and young adults after vaccination.
Last October, the Florida Department of Health issued a warning against giving young men mRNA COVID shots, citing an analysis (pdf) that found “an 84 percent increase in the relative incidence of cardiac-related death among males 18-39 years old” within 28 days following the jab.
“With a high level of global immunity to COVID-19, the benefit of vaccination is likely outweighed by this abnormally high risk of cardiac-related death among men in this age group. Non-mRNA vaccines were not found to have these increased risks,” said Dr. Joseph Ladapo, Florida’s surgeon general.
Read more here...
Best I can tell, the mRNA flu vaccine is supposed to be universal against all strains as it teaches the body to recognize the “stalk” is what it said.
Interestingly, the COVID elixir focused on the spike protein. Unfortunately, the spike was the most toxic part of the virus. Caused all the clotting issues. They gave people a shot that caused their body to create this toxic protein, leading to severe reactions in some. (I’ve read Ivermectin works because it interrupts this clotting process.)
Hopefully, this “stalk” isn’t what makes flu lethal for some.
I went to my Chiropractor yesterday. Another guy there said he got GB syndrome from the flu shot. Luckily, he lived. No spring chicken either.
‘I’ll take my chances with the flu.”
Wife and I refused to get a flu shot last year due to mistrust.
of course, we both got some sort of bug after traveling. Dunno if the flu or what. Taking a while to dissipate.
We almost never get sick, living in a constant climate.
I’ll bet *We* (or someone) knows for sure.
Otherwise, I don ‘t see the motivation to push the vaxxes so hard, because one thing I am convinced of, is that it was not out of genuine concern for the health and safety of the hoi polloi that the elitists did it.
TIK: You will recall a recent comment where I expressed concern about the changes in ratios of IgG 1 thru 4 immune components after multiple vaccine shots. At first I thought this might be caused by mRNA in the 2 most used vaccines in the US. However I have since verified that J&J (of which I had 2 shots) also targets spike protein as do the mRNA vaccines. The quote below reflects the answer found in several studies.
“But the end result is the same: both the mRNA vaccines and the Johnson & Johnson vaccine help your body to develop antibodies against the coronavirus spike protein.”
After Christmas my partner became ill both times after he spent a full day babysitting his toddler grandson who was home sick from preschool. In a few days I had the same illness. The most outstanding symptom was a deep mucus laden cough, which for me was similar to bronchitis I would get last century. The second illness gave him chills and me chills and fever. We were constantly symptomatic for over 3 months. He was sicker and longer, and I could not persuade him to take as many anti covid/illness supplements as i did. These included,most routine supplements, plus Vitamins D3 and frequent C, as well as NAC, Quercetin, and Zinc (I lost my sense of smell, but trippling my zinc consumption brought back my smell ability in 5 days). We both used various over the country cold and allergy medications. I used a Musinex type for a while. We never thought it necessary to see a doctor (my psrtner’s son is a doctor and we did not consult him). Partner is 78, I am 84. [What kind of doctor asks his 78 year old father to care for a sick toddler 3 months after finishing radiation treatment for prostate cancer, and while ablation treatment is pending for tackycardia???]
At any rate we are finally well again, although I feel like i have aged 5 years. And partner promises no more babysitting sick grandson. Around last Christmas he had his fourth mRNA vaccine (aginst my advice) and I had a flu shot (my 2 J&Js were in 2021).
At this point I have tried to determine if flu shots also target the spike protein but could not clarify that point from reading various studies on flu and vaccines. They are working on an mRNA flu vaccine. If flu vaccines do? target spike proteins, it may be that one annual shot may not affect the IgG 1 thru 4 immune component significantly.
UNFORTUNATELY, research on mRNA vaccine users suggest a major derangement of the IgG 1-4 system. Based on a small study it appears IgG4 increases from less than 1% to an average near 20% and for around 30% of participants to around 50% after 3 vaccine shots. After multiple shots IgG4 teaches the body to ignore a targeted substance such as in pollen allergy shots. This seems dangerous with multiple shots affecting viruses, which unlike pollen CAN grow in the body. Another derangement is with IgG3 which is the MOST effective IgG for stopping viruses. After 3 mRNA Covid shots IgG3 completely disappeared. So we have one part of IgG which increases in volume and ignores viruses, while the IgG part which fights viruses disappears completely. Bigger studies needed.
Something called IgG Related Disease has been known for a while. However this is all new information found since 2021 as a result of concern for odd effects that seem to be caused by Covid vaccines. These include sudden death, severe illness (including cancer). increased deaths in younger victims, and “long Covid”.
MUCH RESEARCH NEEDS TO BE DONE ON THESE ODD EFFECTS ON THE IgG IMMUNE COMPONENT. Probably all immune components should be looked at in MUCH greater detail. One thought I recently had was: could the much larger number and frequency of infant and child vaccinations be a cause of AUTISM?
”Something called IgG Related Disease has been known for a while.
However this is all new information found since 2021 as a result of concern for odd effects that seem to be caused by Covid vaccines.
These include sudden death, severe illness (including cancer). increased deaths in younger victims, and “long Covid”.
”MUCH RESEARCH NEEDS TO BE DONE ON THESE ODD EFFECTS ON THE IgG IMMUNE COMPONENT.
Probably all immune components should be looked at in MUCH greater detail “
(My Comment):" Another derangement is with IgG3 which is the MOST effective IgG for stopping viruses."
Realize that the vaccine was approved in a rush, with many unknowns: longevity, transmigration within the human body to organs, and long term effect on future generations, etc., etc.
I agree, there needs to be further study with the effects on the various supporting components within the immune system.
There are so many unknowns, and given past history, I am not sure that NIAID/ NIH/ CDC are up to the task of conducting or funding a 'deep study' on immune components.
“...given past history, I am not sure that NIAID/ NIH/ CDC are up to the task of conducting or funding a ‘deep study’ on immune components.
Is there any improvement in their officials now that Fauci and others have retired? Is there someone in Congress we could alert?
Disclaimer: Opinions posted on Free Republic are those of the individual posters and do not necessarily represent the opinion of Free Republic or its management. All materials posted herein are protected by copyright law and the exemption for fair use of copyrighted works.