Posted on 05/14/2023 5:17:28 PM PDT by ConservativeMind
Investigators found that fatty liver promotes the spread of colorectal cancer to the liver.
Said Ekihiro Seki, MD, Ph.D.: "Our study found that fatty liver cells secrete sacs of proteins and genetic material that promote the spread of colorectal cancer to the liver, suggesting doctors should manage colorectal cancer patients with fatty liver differently."
"Our study showed that even mild fatty liver increased the risk of cancer spread," Seki said. "Thus, we are urging doctors to really pay attention to colorectal cancer patients who might have fatty liver. Among our patient samples, we noted that more than 40% of patients had fatty liver, but doctors often do not order the specialized MRI required to detect it, meaning many cases are missed."
Ultimately, 70% of patients with colorectal cancer will develop liver metastasis, which is the major cause of death for these patients, according to Seki. He sought to discover why some patients develop aggressive metastasis while others do not, and to determine why only some patients respond to therapy.
Seki and his team examined laboratory mice with colorectal cancer liver metastasis, some of which had been fed a high-fat diet that caused them to develop fatty liver. They noted that liver cells in the mice with fatty liver produced greater amounts of extracellular vesicles—particles that are released from cells and carry proteins and genetic material from the parent cell.
"The extracellular vesicles produced by fatty liver cells contain three types of microRNA that stimulate cancer proliferation, migration and invasion," Seki said. "The cancer cells take in these extracellular vesicles and these microRNA react with another protein called yes-associated protein to promote tumor growth."
These yes-associated proteins also suppress the immune system in the environment immediately surrounding tumors, which Seki theorized could make them resistant to immunotherapy, a common cancer-fighting treatment.
(Excerpt) Read more at medicalxpress.com ...
With patient populations, 40% of all colon cancer patients had fatty liver, which is higher than the general population.
Diet, exercise, other ways of losing weight all can eliminate fatty liver. Additionally, pantethine was found in one study to eliminate it in over 50% of participants after six months of two 300 mg capsules a day, which is something I previously put on here.
Seriously though, this sounds like a circular problem where the liver contaminates the intestine which, in turn, causes cancer back in the liver. Supposing a person has the bad habits to trigger such a malady would the heavily advertised ColoGard warn you in time to correct it?
Very helpful. I had colon cancer and fatty liver. I later developed liver cancer, which is also very common.
“Diet, exercise, other ways of losing weight all can eliminate fatty liver. Additionally, pantethine was found in one study to eliminate it in over 50% of participants after six months of two 300 mg capsules a day”
Thanks for that!
Hope you’re doing OK now.
With my history of IBD, I’m a candidate for colorectal cancer. Gotta watch my diet better. At least I don’t drink alcohol anymore.
Surgically removed partial colon and radiation and chemo on the liver. Doing fine, but I strongly recommend watching your diet.
Very interesting article. I’m thinking this quote from the article is out of context?
“Ultimately, 70% of patients with colorectal cancer will develop liver metastasis,”
Colorectal cancer is 91% curable when detected early. I’m doubting that 70% of all patients die. Am I mistaken?
I certainly will, thanks!👍
That is good. Most people believe that you only get fatty cirrhosis by drinking alcohol, but at least 20 million Americans developed non-alcoholic fatty liver (cirrhosis). The effects are just as deadly whether you drink or not. I haven’t drank any alcohol in more than a decade, but the other stuff sure didn’t help.
I had cirrhosis due to two autoimmune diseases.
It cost me my liver, I was lucky enough to receive a new one almost two years ago. No alcohol because my meds and alcohol don’t play nice together, plus I just plain FEEL BETTER, not having any alcohol in my system….😀
Metastasis does not necessarily mean death.
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