Dupilumab beneficial for adults with prurigo nodularis

Medical Xpress / University of Miami / Nature Medicine ^ | May 10, 2023 | Elana Gotkine / Gil Yosipovitch et al

[ConservativeMind]

For adults with prurigo nodularis (PN), dupilumab, a fully human monoclonal antibody that blocks the shared receptor component for interleukin (IL)-4 and IL-13, demonstrates clinically meaningful and significant improvements in itch and skin lesions in two phase 3 trials (LIBERTY-PN PRIME and PRIME2), according to a study.

Gil Yosipovitch, M.D. and colleagues randomly assigned adults with PN with ≥20 nodules and severe itch uncontrolled with topical therapies to dupilumab or placebo subcutaneously every two weeks for 24 weeks. Pruritus improvement, measured by the proportion of patients with a ≥4-point reduction in Worst Itch Numeric Rating Scale (WI-NRS) from baseline at week 24 (PRIME) or week 12 (PRIME2), was the primary end point.

A total of 151 and 160 patients were enrolled in PRIME and PRIME2, respectively. The researchers found that both trials met all primary and key secondary end points. A ≥4-point reduction in WI-NRS was achieved at week 24 by 60.0 and 18.4 percent of patients in the dupilumab and placebo arms, respectively, in PRIME and at week 12 by 37.2 and 22.0 percent of patients, respectively, in PRIME2.

"These positive studies support the involvement of type 2 cytokines in driving PN disease pathogenesis and the targeting of the IL-4/IL-13 axis as a novel therapeutic paradigm for patients with PN," the authors write.

[ConservativeMind]

Some help for an itchy problem.

Dupilumab is available today.

[Harmless Teddy Bear]

I often have to look up things in the articles you publish but this is the first time I have read one and not had the faintest idea of what it is about. Except it seems to be about an itch you can't scratch. :)

Oh well it will make an interesting look up project for tomorrow when things are slow.

[lizma2]

I’m a doc and have never heard of prurigo nodularis.

Your post teach me!!!

[03A3]

Far more interested in its effect on Type 2 inflammation than just eczema.

[Grampa Dave]

What is prurigo nodularis?

Prurigo nodularis is a chronic skin disorder characterized by the presence of hard, extremely itchy bumps known as nodules.

Though the cause of the condition is unknown, the nodules are the result of persistent, intense scratching and rubbing of the skin.

[Grampa Dave]

What is prurigo nodularis?

Prurigo nodularis is a chronic skin disorder characterized by the presence of hard, extremely itchy bumps known as nodules.

Though the cause of the condition is unknown, the nodules are the result of persistent, intense scratching and rubbing of the skin.

[Apparatchik]

I think that any drug that has opposite effects to another drug should be the name of that drug spelled backward. If dupilumab treated hard skin lesions, then a drug that treats overly soft skin should be called bamulipud.