Posted on 05/10/2023 8:59:51 AM PDT by ConservativeMind
We've all recently gotten a crash-course in drug repurposing, thanks to near-daily news reports about efforts to identify existing medicines that could help treat COVID-19 in the early phase of the pandemic. A team of scientists jumped into the fray in the spring of 2020, applying novel computational drug repurposing approaches to confront the COVID-19 challenge.
In the flurry of clinical studies being published by other scientists studying COVID-19, some found that statins seemed to reduce mortality in COVID-19 patients, while others found no effect—but these studies did not discriminate between different types of statin drugs.
Now, the team have confirmed that only a subset of them, including simvastatin (Zocor) and atorvastatin (Lipitor), reduce mortality risk in COVID-19 patients. The team also demonstrated that simvastatin potently inhibited the virus and reduced the production of inflammatory cytokines, while other statins did not.
The researchers analyzed 2,436 drugs with NeMoCAD, and noticed that a subset of statin drugs were among those predicted to restore a COVID-19 state to a healthy state, including simvastatin, atorvastatin, pravastatin (Pravachol), lovastatin (Altoprev), and fluvastatin (Lescol). However, only simvastatin and atorvastatin were ranked as highly protective; the others showed a much weaker predicted effect.
Together, the groups performed a retrospective analysis of more than 4,000 patients who were actively taking statins when they became infected with SARS-CoV-2. The results showed that only simvastatin and atorvastatin correlated with significantly increased survival in COVID-19 patients.
Additional in vitro studies in living cells found that only simvastatin strongly inhibited the virus' ability to infect non-human primate cells; the other statins tested were either ineffective or toxic at the dose required to achieve any effect. Simvastatin also inhibited the infection of human cells with a related coronavirus known as OC43 and reduced the levels of multiple inflammatory cytokines without causing toxicity.
(Excerpt) Read more at medicalxpress.com ...
I take atorvastatin.........But I never got the Vaxx and also take D3 and other supplements. Not even a sniffle.............
My wife and I have that one covered. Bofum.
Zocor came really close to killing me.
I was on 80mg of Lipitor (atorvastatin) for 4yrs, but the excruciating hip pain was too much to bear, while walking for exercise, with my Lady Friend.
My cardiologist put me on 10mg of Crestor (rosuvastatin) and the pain’s disappeared.
After reading this article, I’m wondering if I should get back on the atorvastatin...
Do you have any hip, leg, spine pain? What dosage are you on?
No pains, 40mg.................
I’ve taken atorvastain and vitamin D for some time now. Did get covid in March of 22. Not a bad case although I did cough up pink phlegm. Not sure if it was from coughing so hard or from lungs.
80mg? I made them cut my Zocor down to 20mg
Same here to both and your result too !
80mg was killing my walking, with excruciating hip pain on both hips.
I’m on 20mg of a different statin now, and there’s no pain, but after reading this article, I’ve emailed my cardiologist, sent him the article, and asked if I should go back on Lipitor at a lower dosage.
I have 5 stents in the heart bundle, since July 2018, and can’t take general anesthesia, so I’m not a candidate for a bypass.
Had a quad bypass in 2020...................
Cutting the dosage in half had no effect on my numbers.
“I was on 80mg of Lipitor (atorvastatin) for 4yrs, but the excruciating hip pain was too much to bear,”
I took atorvastatin for 5 years before I connected it to my lower body peripheral neuropathy, tingling and numbness growing worse and worse in my feet. After I saw an article I decided to do a test and quit the statin cold turkey. My neuropathy got about 50% better and stopped progressing. Can’t undo all the damage after 5 years on that stuff.
Atorvastatin does good for many in control of cholesterol, but I’m lucky I quit when I did. If you tolerate it, that’s great but be aware of the side effects, even if they are not common.
https://www.aan.com/PressRoom/Home/PressRelease/82
My elderly mother was taking cholesterol-reducing drugs in the latter part of her life. About a year or two before she passed away, a new cancer doctor asked why? He said at 87, what did it matter what her cholesterol levels were. She should eat what she wanted within reason and to throw away those prescriptions. He said he never recommended statins for the elderly as long as they ate reasonably healthy diets.
I also have peripheral neuropathy in my feet, but that was from 23 days in the hospital, and not walking all that time. It’s slightly better now that I’m on a different statin.
My doctors put me on low-dose atorvastatin when they thought I had heart disease.
Via several tests—it was proven that I have NO heart disease whatsoever! My cardiologist fired herself. But I still remain on low-dose atorvastatin, which keeps my lipid numbers very low.
Now I am told that that may help protect me from COVID. Good! I take vitamin D and zinc, too.
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