Posted on 05/06/2023 6:31:54 AM PDT by ConservativeMind
Supplementing GlyNAC—a combination of glycine and N-acetylcysteine as precursors of the natural antioxidant glutathione—improved or reversed age-associated cognitive decline in old mice and improved multiple associated defects in the aging brain.
Sekhar and his team worked with three groups of mice. Two groups were aged naturally side-by-side until they were 90 weeks old, which is similar to a 70-year-old person. At 90 weeks of age, both groups of old mice were evaluated for their cognitive abilities, such as remembering the correct route in a maze that leads to a food reward.
These results were compared to those of young mice, the third group. Then, one group of old mice began a GlyNAC-supplemented diet, while the other group, called the old-controls, continued their regular diet without GlyNAC supplementation.
After completing eight weeks on their respective diets, the animals' cognitive abilities were evaluated again.
Sekhar said: "Compared to young mice, old mice had cognitive impairment and many brain abnormalities such as glutathione deficiency, increased oxidative stress, impaired mitochondrial function, elevated inflammation, genomic damage and lower levels of brain-supporting factors. Importantly, we found evidence that there was a shortage of transporters responsible for moving glucose, the main fuel for the brain, into this organ."
"This problem gets worse because the mitochondria, the engines that burn glucose to provide energy, were also not working well in the brain."
GlyNAC supplementation in old mice corrected brain glutathione deficiency, improved brain glucose transporters, reversed mitochondrial dysfunction and improved cognition. In addition, GlyNAC supplementation reduced oxidative stress, inflammation and genomic damage and improved neurotrophic factors.
Previous studies reported that GlyNAC supplementation improved similar biological defects in the heart, liver and kidneys, and also increased length of life, provided improvements in skeletal muscle and blood and reversal of aging hallmarks.
(Excerpt) Read more at medicalxpress.com ...
Do note NAC interferes with apoptosis activities from antioxidants. It is also used by some cancers to protect themselves, too.
We do need cysteine (and glycine) for proper functioning and our bodies do not provide enough as we age. Supplementing makes sense, and I do take 1,800 mg a day of glycine and the same of NAC (both are cheap). I take them together for maximum glutathione conversion benefit, as Nestlé and Baylor suggest.
So,,,
Safe and effective eh ?
Pharm has destroyed all trust except with Marxist zombies.
Imho.
I retract that knee jerk reaction, not everyone is a Marxist or zombie.
( it just seems like it )
My trust in pharma remains destroyed though.
Brand? Source? Sounds interesting
I don’t trust big Pharma, either. However, the fact that the FDA wanted NAC taken off the shelves during Covid speaks volumes. GlyNAC is a very effective treatment, not just for cognitive decline and kidney function, but also for boosting one’s immune system. Big Pharma doesn’t like NAC because they can’t make money on it anymore. It used to be a prescription drug, until the late 1980s. Note that it is still used in the event of acetaminophen poisoning, as it has fantastic effects in protecting the liver.
Life Extension sells NAC, and they are very careful about the purity and bioavailability of the vitamins, etc. that they sell. Note that thet were one of a very few vendors who kept selling NAC when the FDA pressured everybody to take it off the shelves during Covid. My own personal feeling is that they should be rewarded for standing up to big Pharma and it’s bought and paid for federal bureaucrats.
An old term, patent medicine, is descriptive. Generally, supplements are not patented and are cheap. Patent medicines, such as are sold by big pharma, are expensive until they become generic.
At this point, I am extremely leary of mRNA technology. We were told the covid (mRNA) vaccine was safe and effective. It was experimental. It was not effective. It appears that it was not even safe. It does not even meet the old definition of vaccine.
Who were the purveyors of misinformation? Just about everyone. Better to list the few who were right.
I’ve only heard good things about NAC over several years. Glycine? It’s worth a try IMO. NAC and Glycine should be safe, one hopes effective. This is not a Big Pharma product.
Bkmk
Interesting article. Glycine is readily available in many common foods, and our bodies also make some, so it seems unecessary to me to supplement it. Supplementing NAC, or glutathione itself, seems adequate. Oral glutathione is absorbed to a useful extent https://pubmed.ncbi.nlm.nih.gov/24791752/
“GlyNAC supplementation found to improve cognitive decline ...”
Why would you want to “improve” your cognitive decline?
Just sayin’.
For glycine, I just get the cheapest large container of powder I can find.
For NAC, I use Swanson.
I’ve posted multiple GlyNAC study articles, here on Free Republic.
I’ve added these to the supplement stack as a result of those earlier articles.
Do you think stomach acids may degrade the glycine powder?
Dang-it I wish I were a mouse- they get all the good stuff
Yes, thanks. Real studies were done and it seems promising.
The studies were done with capsules that do not protect against stomach acid.
Our bodies stop making enough glycine, as we age.
Baylor showed this, in a prior study.
I was asking about the glycine powder you take personally. Do you worry that the powder is degraded by your stomach acid? The reason I ask is that I can get a bag of each...glycine and NAC...in powder form form substantially cheaper than comparably amounts in capsule form.
I’m other words, is it ok to take both in powdered form, in measured amounts...probably 1800mg.?
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