Posted on 04/23/2023 2:46:29 PM PDT by ConservativeMind
Researchers show that use of senolytics can improve the reparative properties of human heart cells by eliminating senescent "zombie cells," known to be associated with cardiovascular disease and other age-related conditions
Aging is the greatest risk factor for many life-threatening disorders, including cardiovascular disease and cancer. "Senescence" is the term given to the biological aging process which involves the build-up of senescent cells, called "zombie" cells, which refuse to die.
Zombie cells release chemicals that can be harmful to nearby cells, affecting cell survival and reparative potential. The build-up of these zombie cells in our bodies promotes aging and age-related conditions, including cardiovascular disease.
Professor Georgina Ellison-Hughes recently tested a new group of drugs, known as "senolytics," which eliminate zombie cells.
In lab studies, senolytics have been shown to improve poor physical function and extend health span and lifespan.
For this study, the researchers used a lab model where zombie human heart cells are grown together with healthy human heart cells; cardiomyocytes (the contractile cells of the heart) and endothelial cells (vasculature cells).
The results of the study show that human senescent "zombie" cells decrease survival and cell cycle activity of human cardiomyocytes or endothelial cells. If you eliminate the senescent cells using senolytics (Dasatinib and Quercetin), this improves cardiomyocyte survival and cell cycle activity, and the ability of endothelial cells to migrate and form new blood vessels.
"In a human cardiac cell system we show that senescent cell removal by senolytics shows therapeutic potential in rejuvenating the reparative activity of human cardiomyocytes and endothelial cells. These exciting results open the path to further studies using senolytic therapy to treat age-related heart disorders and the toxic effects of cancer chemotherapy on the heart," says Professor Georgina Ellison-Hughes.
The removal of senescent cells shows promise in rejuvenating the heart's reparative potential.
(Excerpt) Read more at medicalxpress.com ...
I do take fisetin as a single dose, which is like a normal antioxidant, but not at the once-a-month mega dose size (14-15 pills) I once did.
The rest is correct.
I don’t take it at all. I did during Covid but something didn’t seem right.
I now know I have P450 issues which is why it probably was not sitting right with me. Once I get all the P450 issues resolved I will relook at Quercetin. By the way, if you have a no function CYP2D6 you may have an issue with tyramine in the brain not being metabolized to dopamine
Given my experience, I would say way more than 60% of the people here have no clue as to whether they have a P450 problem and most of the people here aren’t even aware of P450 issues.
Elvis fans should read this
Also, if you want to know what drug interactions you may have you can get a DNA test from Nebula and upload it to genetic genie and it will pull up SOME of the drug issues. It also shows issues with the transporters of drugs.
I have many screwed up genes that affect drug issues.
One more thing...if you are on warfarin your Doctor should have checked if you have issues. There are some drugs where Doctors will check but they may not do a panel test. It is expensive to get done through your Doctor’s office. Nebula does the whole body for a reasonable price.
I currently take quercetin and and fisetin. I’ll typically mix them with yogurt because I understand they are fat soluable.
This is the first I’ve heard of P450. But I’ve never had any problems with quercetin or any other supplement. So I have to assume that I don’t have the P450 issue.
I don’t know what this means: “if you have a no function CYP2D6”. I gather that you mean that if CYP2D6 is not functioning properly then I might have an issue with tyramine in the brain.
I don’t think that I have any cognitive problems beyond a bad case tinnitus.
Last year I did try to take Rapamycin. But it felt too me like it caused cognitive decline for a day. So I stopped.
There are a number of P450 enzymes. You can have defective from both parents or one parent.
I have 5 defective cyp2d6 SNPs. One of them is NO function. Meaning..ZERO function.
Anyone taking warfarin needs to be aware of the issue because there are multiple P450 issues.
It is a VERY complex issue.
If you look at drug tables Hydroxychloriquine wasn’t on the table...but now a new study shows it should be. So basically just because you think a drug is safe as it pertains to p40 issues..it might not really be safe.
here is an example
if you have CYP2d6 that is ZERO function..and CYP3A that is also problematic but CYP2c8 that is normal...how do you adjust HCQ and what do you need to avoid if you P450 enzymes are whacked out
https://dmd.aspetjournals.org/content/early/2022/11/29/dmd.122.001018
This is so technical that I think regular Doctors may not be educated enough...you need a clinical pharmacology consult
btw, if you ever get your DNA tested you need to look at the CYP3A results.
Cytochrome P-450 3A enzymes are responsible for biotransformation of FK506 and rapamycin in man and rat
https://pubmed.ncbi.nlm.nih.gov/1385058/
“Effects of quercetin on the bioavailability of doxorubicin in rats: role of CYP3A4 and P-gp inhibition by quercetin”
https://pubmed.ncbi.nlm.nih.gov/21544726/
“Quercetin, a flavonoid, is an inhibitor of P-glycoprotein-mediated efflux transport, and its oxidative metabolism is catalyzed by CYP enzymes.”
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