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Lung cancer outcomes significantly improved with immunotherapy-based treatment given before and after surgery (Durvalumab = 4X better outcomes)
Medical Xpress / Univ of Texas M. D. Anderson / Am Assoc for Cancer Res (AACR) Annual Mtg ^ | April 16, 2023 | John Heymach, M.D., Ph.D. et al

Posted on 04/23/2023 11:05:46 AM PDT by ConservativeMind

A regimen of pre-surgical immunotherapy and chemotherapy followed by post-surgical immunotherapy significantly improved event-free survival (EFS) and pathologic complete response (pCR) rates compared to chemotherapy alone for patients with operable non-small cell lung cancer (NSCLC), according to Phase III trial results presented by researchers.

The AEGEAN trial evaluated durvalumab given perioperatively, meaning therapy is given both before and after surgery. Participants on the trial received either pre-surgical (neoadjuvant) durvalumab and platinum-based chemotherapy followed by post-surgical (adjuvant) durvalumab or neoadjuvant placebo and chemotherapy followed by adjuvant placebo.

"Throughout decades of research with adjuvant and neoadjuvant chemotherapy, we only succeeded in increasing cures by around 5%," said John Heymach, M.D., Ph.D. "This one study alone has the potential to increase that percentage significantly, and we look forward to many more improvements going forward."

Of the patients receiving perioperative durvalumab, 17.2% had a pCR compared to just 4.3% of those receiving chemotherapy alone. At the first interim analysis of EFS, with a median follow-up of 11.7 months, the median EFS was 25.9 months in the placebo arm, but it had not yet been reached in the durvalumab arm.

These data correspond to a 32% lower chance of patients experiencing disease recurrence, progression events or death with the immunotherapy-based treatment when compared to chemotherapy alone. Approximately four times as many patients treated with perioperative durvalumab plus chemotherapy achieved a pCR when compared to those treated with chemotherapy alone.

The Phase III AEGEAN trial is a randomized, double-blind, placebo-controlled study to evaluate the benefits of perioperative durvalumab added to platinum-based chemotherapy in adults with untreated stage IIA-IIIB NSCLC. A total of 802 patients were randomized 1:1 into each arm. The study's primary endpoints are pCR, assessed by a central lab, and EFS using a blinded independent central review.

(Excerpt) Read more at medicalxpress.com ...


TOPICS: Health/Medicine
KEYWORDS: cancer; immunotherapy; lung; lungcancer
This is available today.
1 posted on 04/23/2023 11:05:46 AM PDT by ConservativeMind
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To: Mazey; ckilmer; goodnesswins; Jane Long; BusterDog; jy8z; ProtectOurFreedom; matthew fuller; ...

The “Take Charge Of Your Health” Ping List

This high volume ping list is for health articles and studies which describe something you or your doctor, when informed, may be able to immediately implement for your benefit.

Email me to get on either the “Common/Top Issues” (20 - 25% fewer pings) or “Everything” list.

2 posted on 04/23/2023 11:06:15 AM PDT by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
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To: ConservativeMind

Thanks for all the health stuff!


3 posted on 04/23/2023 11:38:23 AM PDT by dennisw (This)
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To: ConservativeMind

If you have cancer MD Anderson is the place go; especially if you have a relatively uncommon cancer.


4 posted on 04/23/2023 10:19:00 PM PDT by WASCWatch ( WASC)
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