Prophylactic use of tranexamic acid not beneficial in cesarean delivery

For patients undergoing cesarean delivery, prophylactic use of tranexamic acid does not lead to a lower risk for a composite of maternal death or blood transfusion, according to a study.

Luis D. Pacheco, M.D. and colleagues randomly assigned patients undergoing cesarean delivery at 31 hospitals to receive tranexamic acid or placebo after umbilical cord clamping (5,529 and 5,471 participants, respectively). The primary outcome was a composite of maternal death or blood transfusion by hospital discharge or seven days postpartum.

The researchers found that a primary outcome event occurred in 3.6 and 4.3 percent of participants in the tranexamic acid and placebo groups, respectively (adjusted relative risk, 0.89; 95.26 percent confidence interval, 0.74 to 1.07; P = 0.19). Estimated intraoperative blood loss of more than 1 L occurred in 7.3 and 8.0 percent of those in the tranexamic acid and placebo groups, respectively (relative risk, 0.91; 95 percent confidence interval, 0.79 to 1.05). Interventions for bleeding complications occurred in 16.1 and 18.0 percent of those in the tranexamic acid and placebo groups, respectively (relative risk, 0.90; 95 percent confidence interval, 0.82 to 0.97). The two groups had similar frequencies of thromboembolic events and other adverse events.

"Prophylactic administration of tranexamic acid during cesarean delivery did not lead to a lower risk of maternal death or blood transfusion," the authors write.

It seems a well-intended medicine, but not found to actually help, so it just becomes another possible concern to manage.

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2 posted on 04/14/2023 9:05:57 PM PDT by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)

IIRC, an article posted yesterday claimed that this acid is beneficial.

3 posted on 04/14/2023 10:55:30 PM PDT by muglywump (Seven days without laughter makes one weak.)

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