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Cold is beneficial for healthy aging, finds new study
Medical Xpress / University of Cologne / Nature Aging ^ | April 3, 2023 | Hyun Ju Lee et al

Posted on 04/04/2023 7:01:39 PM PDT by ConservativeMind

Cold activates a cellular cleansing mechanism that breaks down harmful protein aggregations responsible for various diseases associated with aging. A research team has now unlocked one responsible mechanism.

Professor Dr. David Vilchez used a non-vertebrate model organism, the nematode Caenorhabditis elegans, and cultivated human cells. Both carried the genes for two neurodegenerative diseases that typically occur in old age: amyotrophic lateral sclerosis (ALS) and Huntington's disease. Both diseases are characterized by accumulations of harmful and damaging protein deposits—so-called pathological protein aggregations. In both model organisms, cold actively removed the protein clumps, thus preventing the protein aggregation that is pathological in both ALS and Huntington's disease.

A key finding was that the proteasome activity can also be increased by genetic overexpression of the activator. That way, disease-causing proteins can be eliminated even at the normal body temperature of 37 degrees Celsius.

It has long been known that while extremely low temperatures can be harmful to organisms, a moderate reduction in body temperature can have very positive effects. For example, a lower body temperature prolongs the longevity of cold-blooded animals like worms, flies or fish.

Even in humans, a correlation between body temperature and lifespan has been reported. Normal human body temperature is between 36.5 and 37 degrees Celsius. While an acute drop in body temperature below 35 degrees leads to hypothermia, human body temperature fluctuates slightly during the day and even reaches a cool 36 degrees during sleep. Interestingly, a previous study reported that human body temperature has steadily declined by 0.03 degrees Celsius per decade since the Industrial Revolution, suggesting a possible link to the progressive increase in human life expectancy over the last 160 years.

(Excerpt) Read more at medicalxpress.com ...


TOPICS: Health/Medicine
KEYWORDS: chill; chillywilly; cold; lifespan
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Being cooler appears to help us age.
1 posted on 04/04/2023 7:01:39 PM PDT by ConservativeMind
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To: Mazey; ckilmer; goodnesswins; Jane Long; BusterDog; jy8z; ProtectOurFreedom; matthew fuller; ...

The “Take Charge Of Your Health” Ping List

This high volume ping list is for health articles and studies which describe something you or your doctor, when informed, may be able to immediately implement for your benefit.

Email me to get on either the “Common/Top Issues” (20 - 25% fewer pings) or “Everything” list.

2 posted on 04/04/2023 7:02:16 PM PDT by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
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To: ConservativeMind

YES!!

So glad I decided to live in South Dakota!

LOVE THE COLD!


3 posted on 04/04/2023 7:05:35 PM PDT by HypatiaTaught ( Born Free, Live Free, Die Free)
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To: ConservativeMind

I’m 77 and being cold doesn’t help my cause at all....


4 posted on 04/04/2023 7:05:56 PM PDT by ganeemead (Ukraine/Zelensky: Adding an element of chutzpah to ordinary Nazism...)
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To: ConservativeMind

It’ll be about 10 degrees when I get up tomorrow. Windy and a light snow. About 20 degrees at the moment.


5 posted on 04/04/2023 7:06:21 PM PDT by dynachrome (“We cannot save Ukraine by dooming the US economy.” Rand Paul)
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To: ConservativeMind

Now men can tell their wive the reason they keep the bedroom window open during winter: it’s science!


6 posted on 04/04/2023 7:11:39 PM PDT by ConservativeInPA ("How did you go bankrupt?" Bill asked. "Two ways," Mike said. "Gradually and then suddenly." )
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To: ConservativeMind

Never mind that millions of people have retired to a tropical climate and aging people with asthma and arthritis find relief in warmer dry climates, thats just a coincidence.


7 posted on 04/04/2023 7:19:55 PM PDT by GreatRoad ('In a time of universal deceit, telling the truth is a revolutionary act' )
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To: ConservativeMind

Rhoda Morganstern said it. She said she moved to Minneapolis from the Bronx because she figured she’d keep better.


8 posted on 04/04/2023 7:28:26 PM PDT by stanne
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To: ConservativeMind

If this were true life expectancies in new jersey or new york would be longer than in florida. They aren’t.

Its a certain kind of cold. One that isnt too cold that kills you or helps you to get sick. Also factor in shorter days and lower vitamin d production in cold weather periods.

Being down in florida prevents killing cold, or cold that helps you get sick. The kind of cold you want there is refreshing cold, the kind that feels good after being in the warmth and sun, making vitamin d. Air conditioning cold.


9 posted on 04/04/2023 7:31:18 PM PDT by Secret Agent Man (Gone Galt; not averse to Going Bronson.)
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To: ConservativeMind
I like to take long walks in the bracing cold. If you are dressed for it, you will not get frostbite.

On hot humid days, I like to just sit around and drink.

10 posted on 04/04/2023 7:33:07 PM PDT by SamAdams76 (5,016,040 Truth | 87,429,920 Twitter)
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To: ConservativeMind

There goes my plan to retire to the Mid-South from Detroit.😉


11 posted on 04/04/2023 7:37:33 PM PDT by MotorCityBuck (Keep the change, you filthy animal! )
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To: ConservativeMind

Um...no.

For any number of reasons.


12 posted on 04/04/2023 7:41:58 PM PDT by AAABEST ( NY/DC/CA media/political/military industrial complex DELENDA EST)
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To: ConservativeInPA

I keep the window open at night for a different reason.

Think beans...


13 posted on 04/04/2023 7:42:44 PM PDT by Laslo Fripp (Semper Fidelis)
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To: ConservativeMind
Another of many controverted climate change arguments. We need a cooler planet to live longer.

Yet, at the same time folks like Gates and the WEF want to cull the population.

You honestly cannot make this up.

14 posted on 04/04/2023 7:44:30 PM PDT by ealgeone
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To: HypatiaTaught

All cold does is shrink size of male organ.


15 posted on 04/04/2023 7:47:39 PM PDT by entropy12 (Food is most popular anxiety drug, exercise is the least popular.)
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To: ConservativeMind

It seemed to be of limited value to those poor souls on the Titanic.


16 posted on 04/04/2023 7:48:14 PM PDT by Jeff Chandler (THE ISSUE IS NEVER THE ISSUE. THE REVOLUTION IS THE ISSUE.)
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To: ConservativeMind

Donner party . . .


17 posted on 04/04/2023 7:50:03 PM PDT by Jeff Chandler (THE ISSUE IS NEVER THE ISSUE. THE REVOLUTION IS THE ISSUE.)
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To: ConservativeMind

Hmmmm ... guess I should stop setting my heated mattress pad to “high” before I settle in at night during the cold weather days ...

Nope ... I sleep better and deeper when I’m comfy & warm — But I do have a low-level fan on too ... so maybe it balances out ???

Oh ... and the “surf sounds” on Hubby’s white-noise machine helps too — LOL... how did we ever do without all this ??


18 posted on 04/04/2023 7:58:15 PM PDT by twyn1
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To: ConservativeMind
"human body temperature has steadily declined by 0.03 degrees Celsius per decade since the Industrial Revolution"

Another thing Climate Catastrophe causes!!


19 posted on 04/04/2023 8:06:23 PM PDT by ProtectOurFreedom (I don’t like to think before I say something...I want to be just as surprised as everyone els)
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To: ConservativeMind

Is that why Russian babushkas are so hot?
Seems the Russian winters change them very quickly from attractive babes to lumps of lard and wrinkles.


20 posted on 04/04/2023 8:11:30 PM PDT by doorgunner69 (Let's go Brandon)
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