Study: Fiber intake reduces cognitive decline risk in older people with apolipoprotein ε4 allele (Just 5 extra grams helps ~25% of population)

Medical Xpress / University of Barcelona / Age and Ageing ^ | March 22, 2023 | Andrea Unión-Caballero et al

[ConservativeMind]

Fiber intake is associated with a lower risk of developing cognitive decline in those old people with the apolipoprotein E ApoE ε4 genotype, regarded as a genetic risk factor linked to the development of Alzheimer's disease. This is stated in a study.

Apolipoprotein E (ApoE) is a multifunctional protein synthetized and secreted by several cells (hepatocytes, adipocytes, etc.). the ApoE gene, which in humans is found in the chromosome 19, is a polymorphic one and has three codominant alleles (ε2, ε3 i ε4) which lead to different haplotypes or genetic variants.

"Evidence shows that healthy diets, characterized by a high consumption of fiber-rich foods, have a positive impact on cognition, but the specific role of fiber intake plays on the cognitive function is still unknown."

Cristina Andrés-Lacueva notes that "in participants with the ApoE ε4 haplotype, we see that an increase of five grams per day in the fiber intake is already associated with a 30% lower risk of cognitive decline. This shows that an acceptable increase in the daily fiber intake can have an impact."

Moreover, the researchers note that this protecting association is limited to people who carry the ApoE ε4 haplotype. Regarding the participants with other genetic variants of the apolipoprotein E (ApoE ε2 and Apoe ε3), a higher fiber intake was not associated with a lower risk of cognitive decline.

"These results show that old people with the ApoE ε4 haplotype could benefit from a higher fiber intake, and it opens the door to study the interaction between the ApoE genotype and consumption, which has not been characterized to date," concludes Andrea Unión.

[ConservativeMind]

You can get tested for your variant.

5 extra grams of fiber gave a 30% lower risk of cognitive decline, for these people.

It didn’t help the rest of us, in the same way.

[ConservativeMind]

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[dfwgator]

More Colon Blow, Please.

[kaktuskid]

So fiber solves the problem of “sh•t for brains”?

[RoosterRedux]

A high fiber diet, very low carb intake, and coffee raised my IQ 20%. From 60 to 90. I’ll need another 30 points to get good at math though.

[Veto!]

From the very beginning, this topic was destined to accumulate cartoons and other funny stuff. By “stuff” I mean what you think I mean.