Posted on 03/01/2023 1:41:13 PM PST by ConservativeMind
A four-year phase 2 clinical trial demonstrated that a peanut allergy treatment called sublingual immunotherapy, or SLIT, is effective and safe, while offering durable desensitization to peanuts in peanut-allergic children.
SLIT is a treatment using a tiny amount of peanut protein that is the equivalent of only 1/75th of a peanut kernel. It is taken under the tongue, where it is absorbed into the body.
The research shows that a 4 mg dose of peanut SLIT provides strong desensitization that would be expected to protect against accidental exposures to peanut in the majority of children.
…The current trial was designed to answer 2 key questions…: First, the dose of the peanut SLIT was increased from 2mg to 4mg. Second, in a first-of-its-kind approach, patients finishing peanut SLIT who were desensitized and considered to be protected against accidental exposures of peanut, were then taken off of the peanut SLIT treatment for anywhere from 1 to 17 weeks to measure how long the protection would last.
Of the 54 peanut-allergic children participating, 47 completed the treatment with 70% showing protection against accidental exposures of peanut (>800 mg peanut, ~3 peanuts) and 36% showing full desensitization (5,000 mg of peanut, ~16 peanuts). The average threshold after treatment for children in the study was 2,723 mg of peanut compared to 1,700 mg using the 2mg dose in the pilot study. Importantly, despite the higher treatment dose, safety was similar to the pilot study with only 4% of doses causing side effects and most of these involving a temporary itch in the mouth. No side effects required treatment with epinephrine (EpiPen).
Modeling of the time off of peanut SLIT showed that on average, it would take 22 weeks before the desensitization would wear off and the patient would become reactive to small amounts again.
(Excerpt) Read more at medicalxpress.com ...
Oh, BS. Kids outgrow allergies regularly. Just because they outgrew something doesn’t mean what you claim.
All you are doing is displaying your staggering ignorance of the human immune system.
There is a huge difference between a dislike and an allergy.
I both dislike, and have an allergy, to poison ivy. I won’t enjoy rolling in, and eating, poison ivy.
“ All you are doing is displaying your staggering ignorance of the human immune system.”
From your mouth to my rheumatologists ears.
I’m impressed.
“I don’t have a problem with that. I taught my son from an early age to read labels, and I occasionally gave him food containing peanuts so he would be vigilant in protecting himself.
As a toddler, he would scream in pain if he got anything with peanuts on his skin or in his mouth. I thought he would grow out of it, because I’d never heard of peanut allergies before….”
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It sounds like you’ve been handling your son’s condition in a responsible manner. Hopefully this new treatment or something similar could help. And, yes, without any kind of treatment some do grow out of the allergy but some do not.
. And just because you didn’t know anyone with a peanut allergy doesn’t mean there weren’t any.
The ignorance on this thread is astounding. I expect better from freepers.
“Glad your kids outgrew their peanut allergy.”
That’s just it. They never had a peanut allergy. The school told us that they did because they didn’t eat peanut butter. The school assumed because they didn’t eat it, they had peanut allergies.
I think where the thread went off the rails is what we are told by outside influencers versus what we know. My wife and I didn’t know any better so we listened to the teachers and school staff. We were miserable for years isolating our kids from others because we were afraid they would have a bad reaction to peanuts.
I, also, have a bad reaction to peanut butter it seems to add weight very quickly ROFL.
My kid was tested at the dr office. Not school.
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