Posted on 03/01/2023 1:41:13 PM PST by ConservativeMind
A four-year phase 2 clinical trial demonstrated that a peanut allergy treatment called sublingual immunotherapy, or SLIT, is effective and safe, while offering durable desensitization to peanuts in peanut-allergic children.
SLIT is a treatment using a tiny amount of peanut protein that is the equivalent of only 1/75th of a peanut kernel. It is taken under the tongue, where it is absorbed into the body.
The research shows that a 4 mg dose of peanut SLIT provides strong desensitization that would be expected to protect against accidental exposures to peanut in the majority of children.
…The current trial was designed to answer 2 key questions…: First, the dose of the peanut SLIT was increased from 2mg to 4mg. Second, in a first-of-its-kind approach, patients finishing peanut SLIT who were desensitized and considered to be protected against accidental exposures of peanut, were then taken off of the peanut SLIT treatment for anywhere from 1 to 17 weeks to measure how long the protection would last.
Of the 54 peanut-allergic children participating, 47 completed the treatment with 70% showing protection against accidental exposures of peanut (>800 mg peanut, ~3 peanuts) and 36% showing full desensitization (5,000 mg of peanut, ~16 peanuts). The average threshold after treatment for children in the study was 2,723 mg of peanut compared to 1,700 mg using the 2mg dose in the pilot study. Importantly, despite the higher treatment dose, safety was similar to the pilot study with only 4% of doses causing side effects and most of these involving a temporary itch in the mouth. No side effects required treatment with epinephrine (EpiPen).
Modeling of the time off of peanut SLIT showed that on average, it would take 22 weeks before the desensitization would wear off and the patient would become reactive to small amounts again.
(Excerpt) Read more at medicalxpress.com ...
“safe, effective and lasting”
where have I heard that before . . . ?
“provides strong desensitization that would be expected to protect against accidental exposures”
It’s sorta-kinda like a form of post-exposure “Acquired Immunity”.
I was told that doesn’t work.
They better stick to “Science!”, like we’ve been following for 3 years.
The same UNC that is alleged to have worked on the covid “virus?”
Fact is, if we gave every kid peanut butter & jelly sandwiches again, then there probably wouldn’t be any kids with peanut allergies to begin with. This is one of those situations where fear contributed to the majority of the problem.
My son has almost died twice from getting a little bit of peanuts in his stomach.
Well, that’s a shame, but it’s still not wise public policy to choose the strategy that exposes a majority of children to an avoidable risk in order to protect a small minority of children from an unavoidable risk.
I don’t have a problem with that. I taught my son from an early age to read labels, and I occasionally gave him food containing peanuts so he would be vigilant in protecting himself.
As a toddler, he would scream in pain if he got anything with peanuts on his skin or in his mouth. I thought he would grow out of it, because I’d never heard of peanut allergies before.
But he has gone into anaphylactic shock twice because of ingesting peanuts.
Hopefully these breakthroughs will mean that these allergies won't become hereditary. I know I worry about that.
IF he'd been given a pb&j as you suggest he wouldn't be here today.
This is one of those situations where someone posts on a topic they know nothing about.
“Nope. My kid was born with a peanut allergy.”
And that’s a sample size of one. Sure, since it’s your kid that make him important to you, but in the grand scheme of public policy decisions, that’s not really too relevant.
“IF he’d been given a pb&j as you suggest he wouldn’t be here today.”
And yet, because of fears like this, many parents are afraid to give their kids (who were not born with this allergy) any pb&j, and so now a great many children have developed these allergies which were completely unavoidable.
“This is one of those situations where someone posts on a topic they know nothing about.”
And yet the science in the article actually confirms that I do know what I am talking about since it is EXPOSURE to the relevant proteins that is providing relief from the allergy. Which means that very likely exposure to these proteins before the allergy had developed would have prevented it from ever developing in the first place.
But if they are...why don't you expose them to the allergen.....and hope they live.
What an idiot you are.
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Allergy shots to other things are done for the same desensitization effect.
Tell the kid he/she doesn’t have a peanut allergy, and they won’t.
I'm amazed at the level of stupidity on this topic.
And you got your degree in allergy/immunology from what medical school?
Two year olds don’t even know what allergies are.
You’re trying to tell people it’s all in their heads?
Let me be the first to wish a life threatening allergy on you and then we’ll tell you that your anaphylaxis ands swelling is all in your head .
“ Let me be the first to wish a life threatening allergy on you and then we’ll tell you that your anaphylaxis ands swelling is all in your head.”
Thank you for the wishes. Same to you. I was deathly allergic to shellfish as a kid. I eat it now without problems. I have two kids who had peanut allergies as children. Never seen them eat nuts as kids. But they had peanut allergies. At least that is what the school told us. They were never tested but they had peanut allergies. Asked the doctor about it. He asked if they eat peanut butter. They never took an interest to it. But they have peanut allergies.
My daughter ate her first PBJ at 11. My son ate his first PBJ at 9. Know what happened? Nothing! All that time they had peanut allergies because they were told they had it. In 12 years I went to public school, not one kid ever had a peanut allergy.
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