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Researcher identifies potential cause of 'long COVID' (Virus reservoirs - Paxlovid/antivirals help)
Medical Xpress / CU Anschutz Medical Campus / Gut ^ | Feb. 14, 2023 | Greg Glasgow / Valdirene Leao Carneiro et al

Posted on 02/15/2023 2:57:38 PM PST by ConservativeMind

"Long COVID is estimated to affect one out of every five people who get COVID," says Brent Palmer, Ph.D. "It's described as persistent symptoms that last longer than four weeks post-initial infection."

Palmer has a theory as to why long COVID—also known as post-acute sequelae of COVID, or PASC—is happening: viral reservoirs that linger in the body.

"We found a very pronounced high frequency of cytotoxic CD8 T cells in the individuals with PASC," he adds. "These responses were up to 100 times higher in the PASC group than in the individuals who didn't have long-term, persistent symptoms."

Palmer was astonished to see that a few people six months out from their initial infection had nearly 50% of their T cells directed against COVID-19.

Palmer found an inverse correlation between pulmonary function and the frequency of COVID-19-specific T cells in the blood.

"We think it's an overexaggerated immune response that's causing the problem," he says. "It has been shown that individuals who died of severe acute COVID had virus all over their body. When they do autopsies on these individuals, they can find virus in the brain, the kidney, the lung, and the gut."

A subsequent PASC study, shows that the composition of gut bacteria in the stool of individuals with PASC is associated with elevated inflammation markers in the blood, suggesting that there is an association between gut microbiome and systemic inflammation in PASC.

Both studies, Palmer says, suggest that an antiviral medication such as Paxlovid could be an effective treatment for PASC.

"There have been studies in individuals with long COVID that have shown that vaccination causes a modest decrease in symptoms," he says. "Other studies have shown that giving patients Paxlovid can suppress viral replication, and once suppressed, the virus-specific immune response will drop off.

(Excerpt) Read more at medicalxpress.com ...


TOPICS: Health/Medicine
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It may be worth trying antivirals, especially if CD8 T cells are looking nuts.
1 posted on 02/15/2023 2:57:38 PM PST by ConservativeMind
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To: Mazey; ckilmer; goodnesswins; Jane Long; BusterDog; jy8z; ProtectOurFreedom; matthew fuller; ...

The “Take Charge Of Your Health” Ping List

This high volume ping list is for health articles and studies which describe something you or your doctor, when informed, may be able to immediately implement for your benefit.

Email me to get on either the “Common/Top Issues” (20 - 25% fewer pings) or “Everything” list.

2 posted on 02/15/2023 2:58:17 PM PST by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
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To: ConservativeMind

Strikes me as more junk science.


3 posted on 02/15/2023 3:00:16 PM PST by ifinnegan (Democrats kill babies and harvest their organs to sell)
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To: ConservativeMind

Once again, thanks for your kind efforts in monitoring the latest in health news and passing it on to Freepers at large.


4 posted on 02/15/2023 3:00:45 PM PST by Zhang Fei (My dad had a Delta 88. That was a car. It was like driving your living room)
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To: ConservativeMind

Any unvaxxed with long covid?


5 posted on 02/15/2023 3:02:02 PM PST by CJ Wolf ( what is scarier than offensive words? Not being able to say them. )
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To: CJ Wolf

I know of one.


6 posted on 02/15/2023 3:05:16 PM PST by mairdie (Grandfather Jack Bell - miner, reporter, lawman, naturalist - https://youtu.be/Dnnb63UEk9c)
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To: CJ Wolf

I know one, but he subsequently got the vaccine, when it came out. It didn’t help him.


7 posted on 02/15/2023 3:15:18 PM PST by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
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To: Zhang Fei

You are most welcome, Zhang Fei.


8 posted on 02/15/2023 3:15:49 PM PST by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
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To: ConservativeMind

“What we hypothesize is that there’s residual virus somewhere in the body, but it’s not detected by a nasal swab. theorize ... the COVID virus that remains hidden in the body post-initial infection.”

and yet, not one iota of actual evidence is presented in the entire article to support that hypothesis ... all they did was show that T-cells are overactive against covid-19 ... so, it’s just as likely that the T-cells are activated against some protein from the virus that remains in the body ... or possibly even active against a natural, endogenous protein SIMILAR to a covid-19 protein ...


9 posted on 02/15/2023 3:26:49 PM PST by catnipman (In a post-covid world, ALL "science" is now political science: stolen elections have consequences)
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To: CJ Wolf

Me. Initial symptoms were mild several months ago. Now they’re not so mild and I just got back from the doctor.


10 posted on 02/15/2023 3:32:25 PM PST by cuban leaf (My prediction: Harris is Spiro Agnew. We'll soon see who becomes Gerald Ford, and our next prez.)
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To: catnipman

An antiviral wouldn’t likely help against a non-viral entity, yet, antivirals did help.

You have a good point under other circumstances, though.


11 posted on 02/15/2023 3:35:30 PM PST by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
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To: catnipman

Also, do note they said autopsies find a lot of the virus all over the body, in long-termers.


12 posted on 02/15/2023 3:37:25 PM PST by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
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To: cuban leaf

Sorry to hear that. I hope and pray you feel better. What are your symptoms?


13 posted on 02/15/2023 3:38:54 PM PST by CJ Wolf ( what is scarier than offensive words? Not being able to say them. )
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To: CJ Wolf

Symptoms now I mean.


14 posted on 02/15/2023 3:39:39 PM PST by CJ Wolf ( what is scarier than offensive words? Not being able to say them. )
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To: ConservativeMind

*


15 posted on 02/15/2023 3:43:13 PM PST by Songcraft
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To: cuban leaf

Have you considered using Ivermectin and one of the associated protocols? (Dr Z, FLCCC, etc.) A friend of mine had what his doc told him was “long covid” that lasted almost a full year. One week on IVM, Dr Z’s method, and he was back in action.


16 posted on 02/15/2023 3:49:25 PM PST by Non-Compliant_Deplorable
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To: cuban leaf

Dang, good luck man.

Some reading for you.

https://covid19criticalcare.com/treatment-protocols/i-recover-long-covid-treatment/


17 posted on 02/15/2023 5:57:44 PM PST by FreedomPoster (Islam delenda est)
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BKMK


18 posted on 02/15/2023 6:22:21 PM PST by Faith65 (Isaiah 40:31 )
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To: CJ Wolf

This was discussed well before vaxes existed, so yes.


19 posted on 02/15/2023 6:57:29 PM PST by the OlLine Rebel (Common sense is an uncommon virtue./Federal-run medical care is as good as state-run DMV.)
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To: ConservativeMind

Hogwash. There’s evidence the virus goes latent.

I’ve been saying that since 2020, but this research exposes that they are simply NOT studying the virus.

THAT is the real story.


20 posted on 02/15/2023 7:47:29 PM PST by logi_cal869 (-cynicus the "concern troll" a/o 10/03/2018 /!i!! &@$%&*(@ -)
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