Chronic fatigue syndrome is associated with distinct changes in the microbiome (Butyrate and sources like soluble fiber)

Medical Xpress / Cell Press / Cell Host & Microbe ^ | Feb. 8, 2023 | Julia Oh et al / Brent L. Williams et al

[ConservativeMind]

COVID-19 has led to increased focus on a disease with similar hallmarks and symptoms—myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Two studies are taking a closer look at ME/CFS as it relates to the microbiome and the metabolites that microbial species produce.

Both studies found that ME/CFS is associated with reduced levels in the gastrointestinal microbiome of microbes known to produce the fatty acid butyrate.

ME/CFS is a chronic, complex, and systemic disease associated with neurological, immunological, autonomic, and energy metabolism dysfunctions. It is believed in most cases to be triggered by exposure to viruses or other infectious agents.

Oh's analysis showed that patients with short-term disease had a number of changes to their microbiomes with regard to diversity. Most notably, they had a depletion of microbes known to be butyrate producers. Butyrate is important for protecting the integrity of the gut barrier and is also known to play an important role in modulating the immune system.

Chronic fatigue syndrome is associated with distinct changes in the microbiome.

Williams's study used shotgun metagenomic sequencing to look at the microbiomes of people with ME/CFS and also looked at levels of microbial species in the stool. It did look at metabolites in the stool, which demonstrated reduced levels of butyrate metabolites in ME/CFS.

The study from the Columbia team found significant relationships between the severity of fatigue symptoms and levels of specific species of gut bacteria—in particular the butyrate-producing bacterium Faecalibacterium prausnitzii. It also revealed a higher overall load of bacteria in the stool and disturbances in the interactions among bacterial species in patients with ME/CFS.

"These microbiome-symptom relationships present potentially actionable, manipulatable targets for future therapeutic trials," Williams says. "These trials could perhaps focus on dietary, probiotic, prebiotic, or synbiotic interventions and could provide direct evidence that gut bacteria influence chronic symptom presentation."

[ConservativeMind]

Soluble fiber helps gut bacteria produce butyrate. Also, butter helps, but it appears a lot of butter is needed, which may produce other issues.

It’s not completely proven, but what would it hurt to eat more sources of soluble fiber, aside from getting a bit more gas?

Heck, gas is considered by some to be a reason to eat it…

[ConservativeMind]

The “Take Charge Of Your Health” Ping List
This high volume ping list is for health articles and studies which describe something you or your doctor, when informed, may be able to immediately implement for your benefit.

Email me to get on either the “Common/Top Issues” (20 - 25% fewer pings) or “Everything” list.

[Larry Lucido]

I read that as “China Fatigue Syndrome.”

Definitely have that.

[Jeff Chandler]

I have Fatigue Fatigue Syndrome.

[Delta 21]

You simply can not consume “too much” butter or ghee.

Thank you. Now back to your thread.

[Veto!]

I have yogurt with fruit for dessert every night. Yogurt has probiotics. My microbiome is as healthy as can be. Some yogurt has twice as many probiotics but if you have it every night, it doesn’t matter.

If I were taking antibiotics, I’d probably buy “Nancy’s” probiotic yogurt. A dear friend takes too many antibiotics and doesn’t like yogurt, so she buys a bottle o. f probiotics. Garden of Life is a good brand, with bottles for men and for women

[Organic Panic]

... And I thought it was just from my whisky intake....

[sauropod]

.