Posted on 01/30/2023 9:05:31 AM PST by ConservativeMind
Chemotherapy is a commonly used regimen for cancer treatment, but it is also a double-edged sword. While the drugs are highly effective at killing cancer cells, they are also notorious for killing healthy cells in the body.
Recently, "chronochemotherapy" has been gaining interest in the research community.
Chronochemotherapy exploits the fact that human physiological processes, including cell proliferation and differentiation, are regulated by an endogenous timer called the circadian clock.
Researchers studied a group of patients suffering from Diffuse large B-cell lymphoma (DLBCL).
The research team noticed that DLBCL patients received chemotherapy at two different schedules, with some patients receiving morning treatment (8:30 a.m.), while others taking the drugs in the afternoon (2:30 p.m.). All patients received the same cancer treatment (R-CHOP), which is a combination of targeted therapy and chemotherapy, 4 to 6 times in the morning or afternoon at intervals of about 3 weeks.
They analyzed 210 patients to investigate whether there is any difference between morning and afternoon treatment. It was found that female patients who received afternoon treatment had 12.5 times reduced mortality rate (25% to 2%), while the cancer recurrence after 60 months was decreased by 2.8 times (37% to 13%). In addition, chemotherapy side effects such as neutropenia were more common in female patients who received morning treatment.
Surprisingly, there was no difference in treatment efficiency depending on the treatment schedule in the case of male patients.
Unlike female patients, it was found that male patients did not show a significant difference in white blood cell count and bone marrow cell proliferation activity throughout the day, which is the reason why the timing of the treatment had no impact.
(Excerpt) Read more at medicalxpress.com ...
Circadian Rhythm?
This needs to be protested in the strongest manner possible because it is unfair to trans people
i had to wear a pump 24hrs a day, for 8 weeks, before it near killed me...
good luck
Exactly. Years ago a study found people were more likely to die from early morning surgeries.
Hospitals frequently ask you to show up at four in the morning for a procedure. Very few people are used to being awake at that hour.
Disclaimer: Opinions posted on Free Republic are those of the individual posters and do not necessarily represent the opinion of Free Republic or its management. All materials posted herein are protected by copyright law and the exemption for fair use of copyrighted works.