Study suggests vitamin D benefits and metabolism may depend on body weight (>= 25 BMI is problematic)

Researchers have found that vitamin D may be metabolized differently in people with an elevated body mass index (BMI). The study is a new analysis of data from the VITAL trial that investigated taking vitamin D or marine omega-3 supplements.

"The analysis of the original VITAL data found that vitamin D supplementation correlated with positive effects on several health outcomes, but only among people with a BMI under 25," said first author Deirdre K. Tobias, ScD. "There seems to be something different happening with vitamin D metabolism at higher body weights, and this study may help explain diminished outcomes of supplementation for individuals with an elevated BMI."

While the trial found little benefit of vitamin D supplementation for preventing cancer, heart attack, or stroke in the overall cohort, there was a statistical correlation between BMI and cancer incidence, cancer mortality, and autoimmune disease incidence.

"Most studies like this focus on the total vitamin D blood level," said senior author JoAnn E. Manson, MD, DrPH. "The fact that we were able to look at this expanded profile of vitamin D metabolites and novel biomarkers gave us unique insights into vitamin D availability and activity, and whether vitamin D metabolism might be disrupted in some people but not in others."

The researchers found that vitamin D supplementation increased most of the biomarkers associated with vitamin D metabolism in people, regardless of their weight. However, these increases were significantly smaller in people with elevated BMIs.

"We observed striking differences after two years, indicating a blunted response to vitamin D supplementation with higher BMI," Tobias said.

"This study sheds light on why we're seeing 30–40% reductions in cancer deaths, autoimmune diseases, and other outcomes with vitamin D supplementation among those with lower BMIs but minimal benefit in those with higher BMIs," said Manson.

NAC + bromelain denatures the spike protein. NAC + glycine has demonstrated improved motor function and cognition in seniors.

The aversion to pills lead me to a formulation of quercetin and zinc in liquid form. The product is made by "Trace Minerals". Available from Amazon.

If you suspect an embolism, see your doctor ASAP. It sounds like A-Fib is play with discussion of ablation.

The short answer on IgG4 is the immune system switches to IgG4 to treat an antigen as "self" and stop attacking it. The mRNA vaxx produces large volumes of spike protein. Initially that provokes a lot of IgG3 to attempt to neutralize it. At some point the volume of spike triggers a "class switch" to attempt to tolerate instead of neutralize the spike protein. The switch is to IgG4 and away from IgG3. The downside of that switch is the immune system refuses to mount a neutralizing defense against spike protein from that point forward. The spike protein is free to inflict damage without opposition from the immune system.

“It sounds like A-Fib is play with discussion of ablation.” I am not sure what this sentence means. He has tachycardia, not atrial fibrilation. He has been coughing for several weeks, and tonight he had a tachy episode hold at 170 to 180 b/min. He had his forth M jab well before X-mas. Every time he goes out to babysit his grandson, he seems to come home sick. The toddler is in day school now, He was supposed to drive out ab hour this evening, sleep over and babysit from 7:30 am to 2 pm. This was canceled because the child was sick, and I think one of the parents was sick too. Son is a doctor in a large medical organization, and the mother is a pediatric nurse. So far as I am concerned the house is a germ factory/repository and they are going to kill my guy if something doesn’t change. He needs to be left alone to get well.

If hia 4th jab has elevated his IgG4 levels and if that reduces the strength of an immune reaction, then what can fight the spike protein from the jab. I have recently added daily Quercetin, zinc, and now NAC. I think I have some bromelain because I was trying to find digestive things to sooth his GERD. I have suggested he take more C. would that help neutralize the spike protein whick I assume is not like a virus hiding in a cell to be attacked by zinc, altohough if this cough is a cold virus then that should help. Do you have any other ideas?

I discovered there is something called IgG4-RD (related disease) which causes fibrous patches/lumps? in a number of tissues which apparently has been confused by some doctors with cancer. I am wondering if this is the case with my brother’s colon cancer (now cut out) matasteses to his liver which suddenly got worse after his 4th jab. More research needed.

The virus does seem to have the ability to hide in various organs. When inside a cell, it is shielded from the immune system. Preventing replication can be achieved with zinc + ionophore (quercetin, HCQ, ECGC). Other approaches include protease inhibitors. Ivermectin falls in this group. It inactivates the protease on a one-for-one basis by binding to the active site. The Paxlovid product uses ritonavir to inactivate protease in a similar (more expensive) fashion. Protease inhibitors eliminate the protease needed to cut up the polyprotein peptide synthesized off the mRNA into functional protein subunits. The downside is when you exhaust the protease inhibitor, any new protease is free to turn loose on the accumulated polypeptides synthesized causing the "rebound" effect.

Paul Marik says the only way to clear spike protein is via "autophagy". Intermittent fasting, resveratrol and spermidine assist in the process.

Paul Marik on autophagy

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