Posted on 01/14/2023 10:24:05 AM PST by ConservativeMind
Because heat can affect the structure and immunoreactivity of peanuts, researchers recently tested whether a therapy using sequential doses of boiled peanuts followed by roasted peanuts may help children overcome peanut allergies. Their open label, phase 2, single arm clinical trial, generated promising results.
For the trial, 70 children aged 6–18 years old with peanut allergies received 12-hour boiled peanuts for 12 weeks, 2-hour boiled peanuts for 20 weeks, and roasted peanuts for 20 weeks, to a target maintenance dose of 12 roasted peanuts daily.
Fifty-six of the 70 (80%) participants became desensitized to peanuts. Treatment-related adverse events were reported in 43 (61%) participants, 3 of whom withdrew from the trial.
"Oral immunotherapy using boiled followed by roasted peanuts represents a pragmatic approach that appears effective in inducing desensitization and is associated with a favourable safety profile," the authors wrote.
(Excerpt) Read more at medicalxpress.com ...
On a pretty positive note, the most concerning issue was only had by 4% of all participants (from the abstract):
“Medication use associated with treatment-related adverse events was infrequent, with rescue epinephrine use reported by three (4%) participants (0.05 per 1000 doses).”
Access to the full study is $15.
Sorry, South Carolina.
Oh good, I’ll take your portion. :p
I have no idea how any kind of peanut might affect an allergy, for good or ill. What I do know is that I’ve been eating roasted and salted peanuts pretty much my whole life, and I’m now in my 70s. Good stuff. But then, I don’t have an allergy.
This reminds me of Allergy shots. The idea is to expose the patient to small amounts and build up.
I should add my allergy shots were for grass, pollen, and dust.
My only experience with boiled peanuts makes me think that having children eat them would constitute child abuse, regardless of allergies.
Still, a lot of people must like them.
In the 80’s as a NICU nurse, studies came out that showed people with peanut allergies had a cross sensitivity to soy, and the peanut allergies were probably developing because of early exposure soy. That information seems to have gotten buried as they’ve genetically modified our food. I avoid products with soy, and I hear birds won’t eat the genetically modified soy either.
I’ve never had a peanut allergy, but I love boiled peanuts.
As long as you get the salted boiled peanuts.
I feel for those with a peanut allergy. I think about how many different types of nuts I eat, not to mention one of my favorite sammiches...the PBJ. A PBJ sammich gives me a needed boost when I’m working in the yard.
I get it that they are doing this for safety reasons. It has long been known that IGG antibodies to peanuts are generally safe, and IGE antibodies are often deadly. So presumably one could test to see which ab was present before undergoing this testing, which is life threatening.
It occasionally results in anaphylactic shock which is why the places chosen for these inductions/consumptions are always extremely close to an ER team.
Peanut lectins cross the intestinal barrier in all of us.
They are easily found in the blood along with antibodies to them after eating a large snack of peanuts.
https://pubmed.ncbi.nlm.nih.gov/1512792/
Peanut lectins can be detected in the blood after eating peanuts in large amounts. While no studies have been done to determine whether this has health effects, it does show that peanut lectins are absorbed by the body.
https://www.webmd.com/diet/foods-high-in-lectins
I avoid lectins that cross the intestinal mucosa as it has been shown that it destroys tissue while crossing.
It turned out to be a tainted study. But we also avoid soy. And try to keep low on modified foods, like corn.
I couldn’t take the allergy shots, doc said I was too sensitive.
Thanks for posting, I have a dear cousin who is dangerously allergic to peanuts, sending...
Boiled peanuts are huge in Columbus, Georgia. I bought a bag once at a Little League game. yuck.
More and more information is coming out about the success of oral immunotherapy.
I know a person who was extremely deathly allergic to milk, eggs, and nuts who can now tolerate them because of OIT.
If it can work for that person, it can work for anyone.
They're one of God's greatest blessing for us all!
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