Posted on 01/11/2023 4:27:21 PM PST by ConservativeMind
A newly published study sheds light on the biological underpinnings in sex differences in obesity-related disease, with researchers observing "striking" differences in the cells that build blood vessels in the fatty tissue of male versus female mice.
Men are more likely than women to develop conditions associated with obesity such as cardiovascular disease, insulin resistance and diabetes, says Professor Tara Haas.
Haas observed in a 2018 study that when mice become obese, females grow a lot of new blood vessels to supply the expanding fat tissue with oxygen and nutrients, whereas males grow a lot less.
In this latest study, Haas and her co-authors focused on differences in the endothelial cells that make up the building blocks of these blood vessels in fat tissue.
The team used software to help sift through thousands of genes to zero in on the ones that would be associated with blood vessel growth. They discovered that processes associated with the proliferation of new blood vessels were high in the female mice, whereas the males had a high level of processes associated with inflammation.
"It was very striking the extent of inflammation-associated processes that were prevalent in the males," Haas recalls. "Other studies have shown that when endothelial cells have that kind of inflammatory response, they're very dysfunctional, and they don't respond to stimuli properly."
Female endothelial cells replicated faster, while male endothelial cells displayed greater sensitivity to an inflammatory stimulus. By comparing with previously published data sets, the researchers found endothelial cells from aged male mice also displayed a more inflammatory profile compared to female cells.
(Excerpt) Read more at medicalxpress.com ...
It doesn’t work well, for us.
No, it does not. So yes, more exercise and less cooking. (And eating....)
“So yes, more exercise and less cooking. (And eating....)”
How about I eat the same and just smoke more and drink more coffee?
Beth Dutton intermittent diet:
Nothing but coffee and cigarettes until noon. Then eat whatever you want until you start drinking at six. (H/T Roccus!)
Her picture at post 35.
Interesting that Long Covid seems to impact more women than men.
“Women are significantly more likely than men to experience long COVID, with symptoms that follow a distinct clinical pattern, researchers reported today.Jun 21, 2022”
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