Posted on 12/22/2022 9:31:54 PM PST by ConservativeMind
A research team has linked the mutation that causes Huntington's disease to developmental deficits in the brain's oligodendrocyte cells that are caused by changes in metabolism. They found that high doses of thiamine and biotin can restore normal processes. OL cells generate the insulating coating around neurons, called myelin. The study provides detailed insight into the entire process of how these changes in the genes that regulate cell metabolism impair development of OLs, as well as the therapeutic value of treating HD with high doses of thiamine and biotin. Thiamine and biotin are both B vitamins and are involved in a wide range of metabolic processes that help keep the nervous system healthy.
"Our findings validate that the mutation that causes HD leads to maturation deficits in the myelin-producing cells and show that high-dose thiamine and biotin treatment restores normal function of those cells," said Leslie Thompson, Ph.D., co-corresponding author and Donald Bren.
Using advanced modeling methods, researchers confirmed that in mouse and human HD brain tissue, the maturation state of OL cells and their precursors are arrested in intermediate development, impairing production of the myelin that is critical for neuronal health and function. They found that high doses of thiamine and biotin were connected to significant rescue of gene expression changes in OL cells.
"The mechanisms of HD OL pathology and how these changes occur haven't been fully understood," said Ryan Lim, Ph.D., study co-first author and MIND Research Unit project scientist. "Our next steps will be to longitudinally track the effects of thiamine and biotin treatment on HD mice, so that we can further clarify those molecular and cellular processes, assess the efficacy of this therapeutic approach and identify other targets that may benefit HD patients."
(Excerpt) Read more at medicalxpress.com ...
I’m surprised the article did not talk about MS.
In multiple sclerosis, immune cells target oligodendrocytes, which are only located in the central nervous system (the brain and spinal cord). Oligodendrocytes are cells which produce myelin.
bttt
Very high D3 has reversed or stopped deterioration for some MS sufferers.
https://www.thisisms.com/forum/coimbra-high-dose-vitamin-d-protocol-f57/topic27155-105.html
Disclaimer: Opinions posted on Free Republic are those of the individual posters and do not necessarily represent the opinion of Free Republic or its management. All materials posted herein are protected by copyright law and the exemption for fair use of copyrighted works.