Posted on 10/24/2022 1:59:21 PM PDT by ConservativeMind
Pancreatitis is inflammation of the pancreas often associated with long-term alcohol consumption. Recurrent attacks of acute pancreatitis results in chronic pancreatitis, causing weight loss, pain, diabetes, and even pancreatic cancer.
Excessive alcohol consumption is associated with 40–70% of pancreatitis cases.
With repeated episodes of binge drinking the pancreas eventually builds up scar tissues with persistent inflammation, weakening its endocrine and exocrine functions needed to digest food and regulate blood sugar levels. This chronic insult to the organ can cause excruciating pain, malnutrition, diabetes, and death.
Accumulating scientific evidence suggests that continued alcohol consumption with established alcoholic pancreatitis instigates irreversible pancreatic damage due to recurrent episodes of acute pancreatitis by fostering a continuous fibro-inflammatory microenvironment within the pancreas.
"Using an established alcoholic pancreatitis mice model, we have addressed two of the major unanswered questions with regards to the pathogenesis of pancreatitis. We've characterized the pancreas-specific signaling pathways in this process and determined if utilizing novel therapeutic agents can attenuate the severity of alcoholic pancreatitis progression, despite continued alcohol triggers" said Siddharth Mehra, Ph.D.
The microbiome has been implicated in gastrointestinal inflammation as a critical mediator of overall gut health. Urolithin A is a natural compound synthesized by gut bacteria from ingested ellagitannins, a class of hydrolyzable tannins found mainly in pomegranate, berries, and nuts. Previous work from the group has shown that Urolithin A is a potent anti-inflammatory agent in several pre-clinical disease models and exhibits anti-tumor activity in gastrointestinal cancers.
"Our studies have demonstrated that Urolithin A is well tolerated and does not elicit any adverse toxic effects at clinically relevant doses in mice," says Dr. Nagathihalli. The FDA recognizes Urolithin A as a "safe dietary supplement."
"We have shown that Urolithin A can help improve the effectiveness of treating alcoholic pancreatitis despite continued alcohol intake," said Dr. Mehra.
(Excerpt) Read more at medicalxpress.com ...
I’m convinced that alcohol also exasperates cancer risks. I have too many personal examples to quote.
Many people should have zero alcohol.
Yep.
Traffic deaths would decrease by over 80%.
Other health effects would immediately be solved.
There is NO benefit, either personally or societally, from drinking alcohol.
There is not any good that can come from drinking ethanol no matter what anyone tells you. I agree with the other posters here that feeding the body with alcohol helps various cancers develop and grow. It is like feeding lab mice massive amounts of sugar and getting those huge cancer growths.
I’m Philly Irish by birth, so we all know people...
I think it’s about time that we launch a Manhattan Project II to develop ultra-expensive therapeutics that can be used to allow alcoholics to go on drinking without negative health effects. And of course, establish a government support program to help pay for the therapy.
Alcohol is a biocide. Flavored alcohol is a biocide.
It doesn’t “releive” anything, it just deadens.
Deadens senses, deadens the brain and body,
deadens relationships and families.
It’s all a big, transhistorical, well-taxed lie.
I drank enough for a lifetime and I am glad I stopped.
I hope I never drink again and expect I won’t.
I know people that would volunteer. They don’t like meetings, just FYI...
:)
Of course stopping alcohol intake is also helpful
Celltrient has not been available lately. Not even from Nestle. It may be back by now
And you know this how?
I worked with two women both 35-40:years old and they both already suffered from pancreatitis to the point of missing work from it. One was still drinking a lot (she was fired) the other had stopped but was forever dealing with the damage
Wow, some of the responses....actually most.
I’ve done extensive research. You?
It kills brain cells, and I need as many of those as I can get.
I'm all for it!
Finally, some worthwhile medical breakthroughs I can get behind!
With this administration?
Please, alcohol is the only consumer product that hasn't skyrocketed up in price.
Allow us these few pleasures.
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