Posted on 10/20/2022 8:54:00 PM PDT by ConservativeMind
Researchers from were able to identify a new approach for the therapy of colorectal cancer (CRC). In preclinical models as well as in studies on human immune cells, they found that urolithin A, a metabolite product of the pomegranate, sustainably improves the function of immune cells in their combat against cancer.
After treatment with urolithin A, tumor-fighting immune cells, so-called cytotoxic T cells, become T memory stem cells: Potent immune stem cells that, due to their ability to divide, constantly supply the immune system with rejuvenated, non-exhausted T cells. This inhibits cancer growth by directly modulating the immune system.
Current research suggests that one characteristic of tumor diseases is immune dysfunction: Immune cells that are supposed to fight the tumor are specifically suppressed by the surrounding tissue of the tumor, the tumor microenvironment. As a result, T cells, which are the natural immune response against cancer, are restricted in their function, allowing the tumor to grow and spread uncontrollably.
The researchers showed that urolithin A induces a biological pathway that recycles and renews mitochondria, the "power plants" of the cell in T cells, through a process known as mitophagy. Aged and damaged mitochondria in the T cells are thereby removed and replaced by new, functional ones.
This changes the genetic program of the T cells, which are thus more capable to fight the tumor. The researchers demonstrated the therapeutic potential of urolithin A in two ways: On the one hand, urolithin A can be used as a food in the preclinical model, which limits tumor growth and even acts synergistically with existing immunotherapy. On the other hand, the benefits of urolithin A were also observed on human T cells. In vitro treatment with urolithin A rejuvenates human T cells, producing memory T memory stem cells in the laboratory.
(Excerpt) Read more at medicalxpress.com ...
The cheapest forms are via subscriptions on Amazon or a one year subscription from Time Line Nutrition.
Pomegranate conversion rates are poor and only 40% of people have the right bacteria to convert it.
Enough with the stupid health studies onfree republic all the time
You don’t have to read them, but knowing I annoy you is going to make me redouble my efforts now.
😄🤣😁
Thanks ConservativeMind.
*PING* to duckbutt
Bookmark
I have 300 lbs of them frozen. I run them through the juicer and presto. Love them.
man you need to go somewhere else.
My neighbors have the most beautiful yard around. They have 4 pomegranate trees on the side of their yard.
Posting these nonstop government funded subsidized nutritional studies all the time is absolutely ridiculous.
Eat a handful of almonds every day and you have a healthier heart.
Next month eating almonds escalates your cholesterol.
Who gives a flying F about these worthless, stupid studies?
Good luck with your views.
This board is mostly older guys.
They have a natural interest in maintaining their health. Any help with that is appreciated.
Maybe your health is perfect. Maybe you’re only 45. Good for you.
Disclaimer: Opinions posted on Free Republic are those of the individual posters and do not necessarily represent the opinion of Free Republic or its management. All materials posted herein are protected by copyright law and the exemption for fair use of copyrighted works.