Posted on 10/18/2022 4:26:35 PM PDT by ConservativeMind
Not all senescent cells are harmful "zombies" that should be wiped out to prevent age-related disease, according to research, which found that some of them are embedded in young, healthy tissues and promote normal repair from damage.
Scientists have now seen these cells in action in lung tissue, as well as other organs that serve as barriers in the body, such as the small intestine, colon and skin. When they used drugs called senolytics to kill these cells, injuries to lung tissues healed more slowly.
"Senescent cells can occupy niches with privileged positions as 'sentinels' that monitor tissue for injury and respond by stimulating nearby stem cells to grow and initiate repair," said Tien Peng, MD.
Peng said it was understandable that scientists at first viewed senescent cells as purely detrimental. As people age, senescent cells accumulate that have characteristics of old, worn-out cells, including the inability to make new cells. Instead of dying like normal aged cells, they to live on, spewing a cocktail of inflammatory compounds that form the senescence associated secretory phenotype (SASP). These factors are linked to Alzheimer's disease, arthritis, and other age-related maladies including cancer.
The researchers found that senescent cells exist in young and healthy tissues to a greater extent than previously thought, and actually begin appearing shortly after birth. The scientists also identified specific growth factors that senescent cells secrete to stimulate stem cells to grow and repair tissues. Relevant to aging and tissue injury is the discovery that cells such as macrophages and monocytes can activate senescent cells, suggesting that inflammation seen in aged or damaged tissue is a critical modifier of senescent cell activity and regeneration.
"The studies suggest that senolytics research should focus on recognizing and precisely targeting harmful senescent cells, while leaving helpful ones intact," she said.
(Excerpt) Read more at medicalxpress.com ...
Senolytics include quercetin, fisetin, and apigenin, among others, in higher doses. In lower doses, these do not function in those ways.
If it works, don’t mess with it.
How do you like that? Cells they thought were useless actually do useful things.
Who would have thunk that?
“Senolytics include quercetin, fisetin, and apigenin, among others, in higher doses. In lower doses, these do not function in those ways.”
I take all three. Do you have an idea as to the dosage range for any of them that would target only defective cells?
Isn’t this how the zombie apocalypse begins in the movies?
They are saying there is no dosage to target only bad cells.
so are you going to go off quercetin, fisetin, and apigenin.
my impression was that apigenin only targeted cd38 whereas quercetin and fisetin were senolytics that target all zombie cells.
I will finish up these at a low dose only (single capsule) as a normal antioxidant, and not take larger doses.
I believe the better benefits are from GlyNAC, Taurine, and Urolithin A, anyway.
Something I found yesterday, describing a study a few months back on senolytics and the mice used to determine effectiveness:
https://m.youtube.com/watch?v=Q3SX9B0QNWY
Apparently, diverse mice don’t have a benefit, and we are most like the diverse mice.
On the positive side, fisetin didn’t help or hurt senescent cells in the diverse mice.
READ LATER.
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