Direct oral anticoagulants show lower risk for kidney disease progression vs. vitamin K antagonists (12+% less risk of kidney damage)

Medical Xpress / National Kidney Foundation / American Journal of Kidney Diseases ^ | Oct. 5, 2022 | Marco Trevisan et al

[ConservativeMind]

A Swedish cohort study shows 13% (95% CI, 2-22%) lower risk of kidney function decline or kidney failure and 12% (95% CI, 3-20%) lower risk of acute kidney injury with use of direct oral anticoagulants vs. vitamin K antagonists for non-valvular atrial fibrillation.

The relative safety of anticoagulation with direct oral anticoagulants (DOAC) or vitamin K antagonists (VKA) remains inconclusive, particularly with regards to kidney outcomes.

In a cohort of patients with non-valvular atrial fibrillation from Sweden, researchers observed that compared with VKA, DOAC initiation was associated with a lower risk of the composite of kidney failure and sustained 30% eGFR decline, as well as a lower risk of AKI occurrence.

In agreement with trial evidence, DOAC vs VKA treatment was associated with a lower risk of major bleeding, but a similar risk of the composite of stroke, systemic embolism, or death.

Collectively, these findings add to emerging evidence on the safety and effectiveness of DOAC administered for atrial fibrillation.

[ConservativeMind]

These are the expensive alternative to warfarin-type blood thinners.

Many people on warfarin attempt to get no Vitamin K in their diets, on advice of their doctors, yet, Vitamin K is required for life and can be balanced if the doctor and patient do their work to properly allow Vitamin K intake. Short of that, the following DOACs have no problem with Vitamin K.

“There are five DOACs currently on the market: dabigatran, rivaroxaban, apixaban, edoxaban and betrixaban.”

Wikipedia - Anticoagulant

[ConservativeMind]

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[entropy12]

I know what causes heart disease.
Ditto for liver disease.
But I still don’t know what causes kidney failure.

[Ruy Dias de Bivar]

I have an Omniscience heart valve implanted in 1990, and a heart stent implanted in 2006. I am on a high dose of warfarin.

I have had no problems with the warfarin. I am today almost 76 years old and have outlived my dad who died at 70.

[Ruy Dias de Bivar]

And my kidneys still work fine!